Isolate Data
| Patient | Isolate | Region | Year | Species | Subtype | Source | Clone Method |
| 48-7164 | 7164-30611 | Spain | 2003 | HIV1 | B | Plasma | None |
Treatment History
| Order | Regimen | Weeks |
| 1 | PI|NRTI|NNRTI | NA |
RT Sequence
| NRTIMajorDRMs | NRTIMinorDRMs | NNRTIMajorDRMs | NNRTIMinorDRMs | Polys | UnusualMuts |
| M41L, T69D, M184V, L210W, T215Y | K219R | Y181C | T39A, K43Q, E44D, A98S, V111I, V118I, D123E, V179I, G196E, Q197K, T200A, E203D, Q207K, H208Y, R211D, H221Y, L228H, Q242H, T286A, A288S, E297R, I329V, G333E, G359S, A371V, A376S, S379C, K390R, E399D |
| >7164-30611| codons 1-399 PISPIETVPVKLKPGMDGPKVKQWPLTEEKIKALVEICAELEQDGKISKIGPENPYNTPV FAIKKKDSDKWRKLVDFRELNKRTQDFWEVQLGIPHPSGLKKKKSVTVLDIGDAYFSIPL DKEFRKYTAFTIPSINNETPGIRYQYNVLPQGWKGSPAIFQSSMTKILEPFRKQNPDIII CQYVDDLYVGSDLEIEKHRAKIDELRKYLWDWGFYTPDRKYQKEPPFHWMGYELHPDKWT VHPIVLPEKDSWTVNDIQKLVGKLNWASQIYAGIKVKQLCKLLRGAKSLTEVIPLTREAE LELAENREILKEPVHGVYYDPSKDLIAEVQKQEQGQWTYQIYQEPFKNLKTGKYARMRSA HTNDVKQLTEVVQKISTECIVIWGKTPKFRLPIQKETWD |
Protease Sequence
| PIMajorDRMs | PIMinorDRMs | Polys | UnusualMuts |
| M46I, I54A, V82T, I84V, L90M | L33F, K43T, L89V | L10I, I13V, K20R, E35D, M36L, N37H, R41K, K55R, I62V, L63P, I66F, A71V, I72E, Q92K |
| >7164-30611| codons 1-99 PQITLWQRPIVTVKIGGQLREALLDTGADDTVFEDLHLPGKWTPKIIGGIGGFARVRQYD QVPIEFCGHKVEGTVLVGPTPTNVIGRNVMTKIGCTLNF |
References
| Author | Title | Citation |
| Baxter, JD | Genotypic changes in human immunodeficiency virus type 1 protease associated with reduced susceptibility and virologic response to the protease inhibitor tipranavir. | J Virol, 2006 |