<!--#if expr="$title" --> <!--#echo var="title" --> <!--#else --> HIV Drug Resistance Database <!--#endif -->
Stanford University HIV Drug Resistance Database - A curated public database designed to represent, store, and analyze the divergent forms of data underlying HIV drug resistance.

Isolate Data

Patient Isolate Region Year Species Subtype Source Clone Method
48-7164 7164-30611 Spain 2003 HIV1 B Plasma None

Treatment History
Order Regimen Weeks
1 PI|NRTI|NNRTI NA

Protease Sequence
PIMajorDRMs PIMinorDRMs Polys UnusualMuts
M46I, I54A, V82T, I84V, L90M L33F, K43T, L89V L10I, I13V, K20R, E35D, M36L, N37H, R41K, K55R, I62V, L63P, I66F, A71V, I72E, Q92K  
>7164-30611| codons 1-99
PQITLWQRPIVTVKIGGQLREALLDTGADDTVFEDLHLPGKWTPKIIGGIGGFARVRQYD
QVPIEFCGHKVEGTVLVGPTPTNVIGRNVMTKIGCTLNF

RT Sequence
NRTIMajorDRMs NRTIMinorDRMs NNRTIMajorDRMs NNRTIMinorDRMs Polys UnusualMuts
M41L, T69D, M184V, L210W, T215Y K219R Y181C   T39A, K43Q, E44D, A98S, V111I, V118I, D123E, V179I, G196E, Q197K, T200A, E203D, Q207K, H208Y, R211D, H221Y, L228H, Q242H, T286A, A288S, E297R, I329V, G333E, G359S, A371V, A376S, S379C, K390R, E399D  
>7164-30611| codons 1-399
PISPIETVPVKLKPGMDGPKVKQWPLTEEKIKALVEICAELEQDGKISKIGPENPYNTPV
FAIKKKDSDKWRKLVDFRELNKRTQDFWEVQLGIPHPSGLKKKKSVTVLDIGDAYFSIPL
DKEFRKYTAFTIPSINNETPGIRYQYNVLPQGWKGSPAIFQSSMTKILEPFRKQNPDIII
CQYVDDLYVGSDLEIEKHRAKIDELRKYLWDWGFYTPDRKYQKEPPFHWMGYELHPDKWT
VHPIVLPEKDSWTVNDIQKLVGKLNWASQIYAGIKVKQLCKLLRGAKSLTEVIPLTREAE
LELAENREILKEPVHGVYYDPSKDLIAEVQKQEQGQWTYQIYQEPFKNLKTGKYARMRSA
HTNDVKQLTEVVQKISTECIVIWGKTPKFRLPIQKETWD

References
Author Title Citation
Baxter, JD Genotypic changes in human immunodeficiency virus type 1 protease associated with reduced susceptibility and virologic response to the protease inhibitor tipranavir. J Virol, 2006