<!--#if expr="$title" --> <!--#echo var="title" --> <!--#else --> HIV Drug Resistance Database <!--#endif -->
Stanford University HIV Drug Resistance Database - A curated public database designed to represent, store, and analyze the divergent forms of data underlying HIV drug resistance.

Isolate Data

Patient Isolate Region Year Species Subtype Source Clone Method
48-7162 7162-30609 Spain 2003 HIV1 B Plasma None

Treatment History
Order Regimen Weeks
1 PI|NRTI|NNRTI NA

RT Sequence
NRTIMajorDRMs NRTIMinorDRMs NNRTIMajorDRMs NNRTIMinorDRMs Polys UnusualMuts
M41L, T69TADN, L74LV, L210W, T215Y K219N K103N, Y181C   V35T, E44D, V118I, K122E, D123N, V179I, T200A, E203K, Q207E, H208Y, K223E, L228R, T286A, P294T, E297KR, Q334D, K350KR, G359S, A371V, A376T, T386A, K390R  
>7162-30609| codons 1-399
PISPIETVPVKLKPGMDGPKVKQWPLTEEKIKALTEICTELEKDGKISKIGPENPYNTPV
FAIKKKDSNKWRKVVDFRELNKRTQDFWEVQLGIPHPAGLKKNKSVTVLDVGDAYFSIPL
DENFRKYTAFTIPSINNETPGIRYQYNVLPQGWKGSPAIFQSSMTKILEPFRKQNPDIII
CQYMDDLYVGSDLEIGQHRAKIKELREYLWRWGFYTPDNKHQEEPPFRWMGYELHPDKWT
VQPIVLPEKDSWTVNDIQKLVGKLNWASQIYAGIKVKQLCKLLRGAKALTEVITLTREAE
LELAENREILKEPVHGVYYDPSKDLIAEIQKQGDGQWTYQIYQEPFKNLRTGKYARMRSA
HTNDVKQLTEVVQKITTESIVIWGKAPKFRLPIQKETWE

Protease Sequence
PIMajorDRMs PIMinorDRMs Polys UnusualMuts
V32I, M46I, I54V, V82A, L90M L33F, F53L, T74P L10I, I13V, K43I, K55R, L63C, A71V, T91S  
>7162-30609| codons 1-99
PQITLWQRPIVTVKIGGQLKEALLDTGADDTIFEEMNLPGRWIPKIIGGIGGLVRVRQYD
QICIEICGHKVIGPVLVGPTPANIIGRNLMSQIGCTLNF

References
Author Title Citation
Baxter, JD Genotypic changes in human immunodeficiency virus type 1 protease associated with reduced susceptibility and virologic response to the protease inhibitor tipranavir. J Virol, 2006