Isolate Data
| Patient | Isolate | Region | Year | Species | Subtype | Source | Clone Method |
| 48-7162 | 7162-30609 | Spain | 2003 | HIV1 | B | Plasma | None |
Treatment History
| Order | Regimen | Weeks |
| 1 | PI|NRTI|NNRTI | NA |
Protease Sequence
| PIMajorDRMs | PIMinorDRMs | Polys | UnusualMuts |
| V32I, M46I, I54V, V82A, L90M | L33F, F53L, T74P | L10I, I13V, K43I, K55R, L63C, A71V, T91S |
| >7162-30609| codons 1-99 PQITLWQRPIVTVKIGGQLKEALLDTGADDTIFEEMNLPGRWIPKIIGGIGGLVRVRQYD QICIEICGHKVIGPVLVGPTPANIIGRNLMSQIGCTLNF |
RT Sequence
| NRTIMajorDRMs | NRTIMinorDRMs | NNRTIMajorDRMs | NNRTIMinorDRMs | Polys | UnusualMuts |
| M41L, T69TADN, L74LV, L210W, T215Y | K219N | K103N, Y181C | V35T, E44D, V118I, K122E, D123N, V179I, T200A, E203K, Q207E, H208Y, K223E, L228R, T286A, P294T, E297KR, Q334D, K350KR, G359S, A371V, A376T, T386A, K390R |
| >7162-30609| codons 1-399 PISPIETVPVKLKPGMDGPKVKQWPLTEEKIKALTEICTELEKDGKISKIGPENPYNTPV FAIKKKDSNKWRKVVDFRELNKRTQDFWEVQLGIPHPAGLKKNKSVTVLDVGDAYFSIPL DENFRKYTAFTIPSINNETPGIRYQYNVLPQGWKGSPAIFQSSMTKILEPFRKQNPDIII CQYMDDLYVGSDLEIGQHRAKIKELREYLWRWGFYTPDNKHQEEPPFRWMGYELHPDKWT VQPIVLPEKDSWTVNDIQKLVGKLNWASQIYAGIKVKQLCKLLRGAKALTEVITLTREAE LELAENREILKEPVHGVYYDPSKDLIAEIQKQGDGQWTYQIYQEPFKNLRTGKYARMRSA HTNDVKQLTEVVQKITTESIVIWGKAPKFRLPIQKETWE |
References
| Author | Title | Citation |
| Baxter, JD | Genotypic changes in human immunodeficiency virus type 1 protease associated with reduced susceptibility and virologic response to the protease inhibitor tipranavir. | J Virol, 2006 |