Isolate Data
| Patient | Isolate | Region | Year | Species | Subtype | Source | Clone Method |
| 48-7159 | 7159-30604 | Spain | 2003 | HIV1 | B | Plasma | None |
Treatment History
| Order | Regimen | Weeks |
| 1 | PI|NRTI|NNRTI | NA |
Protease Sequence
| PIMajorDRMs | PIMinorDRMs | Polys | UnusualMuts |
| M46I, I54L, V82A, L90M | V11I, L33F, G73S | L10I, I13V, I15V, K20T, E35D, M36I, N37D, K55R, R57K, I62V, L63P, K70E, A71V, I72L |
| >7159-30604| codons 1-99 PQITLWQRPIITVKVGGQLTEALLDTGADDTVFEDIDLPGRWKPKIIGGIGGFLRVKQYD QVPIEICGHEVLSTVLVGPTPANIIGRNLMTQIGCTLNF |
RT Sequence
| NRTIMajorDRMs | NRTIMinorDRMs | NNRTIMajorDRMs | NNRTIMinorDRMs | Polys | UnusualMuts |
| M41L, D67N, L210W, T215Y | K219N, N348I | K103N, Y181C, G190A | K22R, V35I, T39A, E40F, K43E, W88C, L100LF, V118I, K122E, K166R, R172K, I178M, G196E, T200I, R211K, A272P, K277R, S322T, K347KN, M357K, A376S, T386I, K390R |
| >7159-30604| codons 1-398 PISPIETVPVKLKPGMDGPKVRQWPLTEEKIKALIEICAFLEEEGKISKIGPENPYNTPV FAIKKKNSTKWRKLVDFRELNKRTQDFCEVQLGIPHPAGFKKNKSVTVLDVGDAYFSIPL DEDFRKYTAFTIPSINNETPGIRYQYNVLPQGWKGSPAIFQSSMTRILEPFKKQNPDMVI CQYMDDLYVASDLEIEQHRIKIEELRQHLWKWGFYTPDNKHQKEPPFLWMGYELHPDKWT VQPIVLPEKDSWTVNDIQKLVGKLNWASQIYPGIKVRQLCKLLRGTKALTEVIPLTEEAE LELAENREILKEPVHGVYYDPTKDLIAEIQKQGQGQWTYQIYQEPFNILKTGKYARKRGA HTNDVKQLTEAVQKISTESIVIWGKIPKFRLPIQKETW |
References
| Author | Title | Citation |
| Baxter, JD | Genotypic changes in human immunodeficiency virus type 1 protease associated with reduced susceptibility and virologic response to the protease inhibitor tipranavir. | J Virol, 2006 |