<!--#if expr="$title" --> <!--#echo var="title" --> <!--#else --> HIV Drug Resistance Database <!--#endif -->
Stanford University HIV Drug Resistance Database - A curated public database designed to represent, store, and analyze the divergent forms of data underlying HIV drug resistance.

Isolate Data

Patient Isolate Region Year Species Subtype Source Clone Method
48-7159 7159-30604 Spain 2003 HIV1 B Plasma None

Treatment History
Order Regimen Weeks
1 PI|NRTI|NNRTI NA

Protease Sequence
PIMajorDRMs PIMinorDRMs Polys UnusualMuts
M46I, I54L, V82A, L90M V11I, L33F, G73S L10I, I13V, I15V, K20T, E35D, M36I, N37D, K55R, R57K, I62V, L63P, K70E, A71V, I72L  
>7159-30604| codons 1-99
PQITLWQRPIITVKVGGQLTEALLDTGADDTVFEDIDLPGRWKPKIIGGIGGFLRVKQYD
QVPIEICGHEVLSTVLVGPTPANIIGRNLMTQIGCTLNF

RT Sequence
NRTIMajorDRMs NRTIMinorDRMs NNRTIMajorDRMs NNRTIMinorDRMs Polys UnusualMuts
M41L, D67N, L210W, T215Y K219N, N348I K103N, Y181C, G190A   K22R, V35I, T39A, E40F, K43E, W88C, L100LF, V118I, K122E, K166R, R172K, I178M, G196E, T200I, R211K, A272P, K277R, S322T, M357K, A376S, T386I, K390R K347KN
>7159-30604| codons 1-398
PISPIETVPVKLKPGMDGPKVRQWPLTEEKIKALIEICAFLEEEGKISKIGPENPYNTPV
FAIKKKNSTKWRKLVDFRELNKRTQDFCEVQLGIPHPAGFKKNKSVTVLDVGDAYFSIPL
DEDFRKYTAFTIPSINNETPGIRYQYNVLPQGWKGSPAIFQSSMTRILEPFKKQNPDMVI
CQYMDDLYVASDLEIEQHRIKIEELRQHLWKWGFYTPDNKHQKEPPFLWMGYELHPDKWT
VQPIVLPEKDSWTVNDIQKLVGKLNWASQIYPGIKVRQLCKLLRGTKALTEVIPLTEEAE
LELAENREILKEPVHGVYYDPTKDLIAEIQKQGQGQWTYQIYQEPFNILKTGKYARKRGA
HTNDVKQLTEAVQKISTESIVIWGKIPKFRLPIQKETW

References
Author Title Citation
Baxter, JD Genotypic changes in human immunodeficiency virus type 1 protease associated with reduced susceptibility and virologic response to the protease inhibitor tipranavir. J Virol, 2006