Isolate Data
| Patient | Isolate | Region | Year | Species | Subtype | Source | Clone Method |
| 48-7158 | 7158-30604 | Spain | 2003 | HIV1 | B | Plasma | None |
Treatment History
| Order | Regimen | Weeks |
| 1 | PI|NRTI|NNRTI | NA |
RT Sequence
| NRTIMajorDRMs | NRTIMinorDRMs | NNRTIMajorDRMs | NNRTIMinorDRMs | Polys | UnusualMuts |
| M41L, L74V, L210W, T215CNSY | Y181C, G190A | A98G, V108I, F227L | K20R, K43N, E44D, V118I, K122E, I135T, T200A, E203K, H208Y, R211K, K223E, L228HR, A272P, L283I, I293V, Q334L, G335S, R356K, G359S, A371V, A376T, T386I, K390R |
| >7158-30604| codons 1-400 PISPIETVPVKLKPGMDGPRVKQWPLTEEKIKALVEICTELENDGKISKIGPENPYNTPV FAIKKKDSTKWRKVVDFRELNKRTQDFWEVQLGIPHPGGLKKKKSVTILDVGDAYFSIPL DEDFRKYTAFTIPSTNNETPGIRYQYNVLPQGWKGSPAIFQSSMTKILEPFRKQNPDIVI CQYMDDLYVASDLEIGQHRAKIKELRQYLWKWGFYTPDKKHQEEPPLRWMGYELHPDKWT VQPIVLPEKDSWTVNDIQKLVGKLNWASQIYPGIKVKQLCKLIRGTKALTEVVPLTEEAE LELAENREILKEPVHGVYYDPSKDLIAEIQKQGLSQWTYQIYQEPFKNLKTGKYAKMRSA HTNDVKQLTEVVQKITTESIVIWGKIPKFRLPIQKETWEA |
Protease Sequence
| PIMajorDRMs | PIMinorDRMs | Polys | UnusualMuts |
| V32I, M46I, I47V, I54V, V82A | K43T | L10V, L33M, E35D, N37C, R57K, I62V, L63P, I64V, A71V |
| >7158-30604| codons 1-99 PQITLWQRPVVTIKIGGQLKEALLDTGADDTIMEDMCLPGRWTPKIVGGIGGFVKVKQYD QVPVEICGHKVIGTVLVGPTPANIIGRNLLTQIGCTLNF |
References
| Author | Title | Citation |
| Baxter, JD | Genotypic changes in human immunodeficiency virus type 1 protease associated with reduced susceptibility and virologic response to the protease inhibitor tipranavir. | J Virol, 2006 |