Isolate Data
| Patient | Isolate | Region | Year | Species | Subtype | Source | Clone Method |
| 48-7156 | 7156-30930 | Spain | 2003 | HIV1 | B | Plasma | None |
Treatment History
| Order | Regimen | Weeks |
| 1 | PI|NRTI|NNRTI | NA |
RT Sequence
| NRTIMajorDRMs | NRTIMinorDRMs | NNRTIMajorDRMs | NNRTIMinorDRMs | Polys | UnusualMuts |
| M41L, D67N, M184MV, L210W, T215Y | K219Q | Y188L | P4S, E6D, T7P, V35I, T39A, E44D, K101Q, V111VI, V118I, K122E, I135T, Q174QR, V179L, I202V, R211K, D218E, I293V, K350R, G359S, A371V, K390R |
| >7156-30930| codons 1-400 PISSIDPVPVKLKPGMDGPKVKQWPLTEEKIKALIEICAELEKDGKISKIGPENPYNTPV FAIKKKNSTKWRKLVDFRELNKRTQDFWEVQLGIPHPAGLQKKKSVTVLDIGDAYFSIPL DEDFRKYTAFTIPSTNNETPGIRYQYNVLPQGWKGSPAIFQSSMTKILEPFRKRNPDILI YQYVDDLLVGSDLEIGQHRTKVEELRQHLWKWGFYTPEQKHQKEPPFLWMGYELHPDKWT VQPIVLPEKDSWTVNDIQKLVGKLNWASQIYAGIKVKQLCKLLRGTKALTEVVPLTEEAE LELAENREILKEPVHGVYYDPSKDLIAEIQKQGQGQWTYQIYQEPFKNLRTGKYARMRSA HTNDVKQLTEVVQKIATESIVIWGKTPKFRLPIQKETWEA |
Protease Sequence
| PIMajorDRMs | PIMinorDRMs | Polys | UnusualMuts |
| I54V, V82A | L24I, L33F, F53L | L10I, T12P, K14R, K20V, E35D, M36I, N37D, D60E, I62V, L63P, A71I |
| >7156-30930| codons 1-99 PQITLWQRPIVPIRIGGQLVEALIDTGADDTVFEDIDLPGRWKPKMIGGIGGLVKVRQYE QVPIEICGHKIIGTVLVGPTPANIIGRNLLTQIGCTLNF |
References
| Author | Title | Citation |
| Baxter, JD | Genotypic changes in human immunodeficiency virus type 1 protease associated with reduced susceptibility and virologic response to the protease inhibitor tipranavir. | J Virol, 2006 |