<!--#if expr="$title" --> <!--#echo var="title" --> <!--#else --> HIV Drug Resistance Database <!--#endif -->
Stanford University HIV Drug Resistance Database - A curated public database designed to represent, store, and analyze the divergent forms of data underlying HIV drug resistance.

Isolate Data

Patient Isolate Region Year Species Subtype Source Clone Method
48-7155 7155-30930 Spain 2003 HIV1 B Plasma None

Treatment History
Order Regimen Weeks
1 PI|NRTI|NNRTI NA

RT Sequence
NRTIMajorDRMs NRTIMinorDRMs NNRTIMajorDRMs NNRTIMinorDRMs Polys UnusualMuts
D67N, T69D, K70R, T215F K219Q     K20R, V35T, T39E, V60I, D86E, K101Q, V118I, K122E, E138S, K166R, K173T, D177N, T200A, I202V, Q207E, R211K, F214L, V245T, A272P, K277R, I293V, E297K, Q334N, G335D, T338S, R356K, M357T, G359S, K390KR  
>7155-30930| codons 1-399
PISPIETVPVKLKPGMDGPRVKQWPLTEEKIKALTEICEEMEKEGKISKIGPENPYNTPI
FAIKKKNSDRWRKLVDFRELNKRTQEFWEVQLGIPHPAGLQKKKSVTVLDVGDAYFSIPL
DEDFRKYTAFTIPSINNSTPGIRYQYNVLPQGWKGSPAIFQSSMTRILEPFRTQNPNIVI
YQYMDDLYVGSDLEIGQHRAKVEELREHLLKWGLFTPDQKHQKEPPFLWMGYELHPDKWT
VQPITLPEKDSWTVNDIQKLVGKLNWASQIYPGIKVRQLCKLLRGTKALTEVVPLTKEAE
LELAENREILKEPVHGVYYDPSKDLIAEIQKQGNDQWSYQIYQEPFKNLKTGKYAKTRSA
HTNDVKQLTEAVQKIATESIVIWGKTPKFRLPIQKETWE

Protease Sequence
PIMajorDRMs PIMinorDRMs Polys UnusualMuts
G48V, I54V, V82S, L90M   L10V, K20R, E35D, M36I, R41K, I62V, L63P, A71V, I72IV, I93L  
>7155-30930| codons 1-99
PQITLWQRPVVTIKIGGQLREALLDTGADDTVLEDINLPGKWKPKMIVGIGGFVKVRQYD
QVPIEICGHKVVGTVLVGPTPSNIIGRNLMTQLGCTLNF

References
Author Title Citation
Baxter, JD Genotypic changes in human immunodeficiency virus type 1 protease associated with reduced susceptibility and virologic response to the protease inhibitor tipranavir. J Virol, 2006