Isolate Data
| Patient | Isolate | Region | Year | Species | Subtype | Source | Clone Method |
| 48-7155 | 7155-30930 | Spain | 2003 | HIV1 | B | Plasma | None |
Treatment History
| Order | Regimen | Weeks |
| 1 | PI|NRTI|NNRTI | NA |
Protease Sequence
| PIMajorDRMs | PIMinorDRMs | Polys | UnusualMuts |
| G48V, I54V, V82S, L90M | L10V, K20R, E35D, M36I, R41K, I62V, L63P, A71V, I72IV, I93L |
| >7155-30930| codons 1-99 PQITLWQRPVVTIKIGGQLREALLDTGADDTVLEDINLPGKWKPKMIVGIGGFVKVRQYD QVPIEICGHKVVGTVLVGPTPSNIIGRNLMTQLGCTLNF |
RT Sequence
| NRTIMajorDRMs | NRTIMinorDRMs | NNRTIMajorDRMs | NNRTIMinorDRMs | Polys | UnusualMuts |
| D67N, T69D, K70R, T215F | K219Q | K20R, V35T, T39E, V60I, D86E, K101Q, V118I, K122E, E138S, K166R, K173T, D177N, T200A, I202V, Q207E, R211K, F214L, V245T, A272P, K277R, I293V, E297K, Q334N, G335D, T338S, R356K, M357T, G359S, K390KR |
| >7155-30930| codons 1-399 PISPIETVPVKLKPGMDGPRVKQWPLTEEKIKALTEICEEMEKEGKISKIGPENPYNTPI FAIKKKNSDRWRKLVDFRELNKRTQEFWEVQLGIPHPAGLQKKKSVTVLDVGDAYFSIPL DEDFRKYTAFTIPSINNSTPGIRYQYNVLPQGWKGSPAIFQSSMTRILEPFRTQNPNIVI YQYMDDLYVGSDLEIGQHRAKVEELREHLLKWGLFTPDQKHQKEPPFLWMGYELHPDKWT VQPITLPEKDSWTVNDIQKLVGKLNWASQIYPGIKVRQLCKLLRGTKALTEVVPLTKEAE LELAENREILKEPVHGVYYDPSKDLIAEIQKQGNDQWSYQIYQEPFKNLKTGKYAKTRSA HTNDVKQLTEAVQKIATESIVIWGKTPKFRLPIQKETWE |
References
| Author | Title | Citation |
| Baxter, JD | Genotypic changes in human immunodeficiency virus type 1 protease associated with reduced susceptibility and virologic response to the protease inhibitor tipranavir. | J Virol, 2006 |