Isolate Data
| Patient | Isolate | Region | Year | Species | Subtype | Source | Clone Method |
| 48-7152 | 7152-30901 | Spain | 2003 | HIV1 | B | Plasma | None |
Treatment History
| Order | Regimen | Weeks |
| 1 | PI|NRTI|NNRTI | NA |
RT Sequence
| NRTIMajorDRMs | NRTIMinorDRMs | NNRTIMajorDRMs | NNRTIMinorDRMs | Polys | UnusualMuts |
| M41L, D67N, K70R, V75M, M184V, L210W, T215Y | K219E | Y181C, G190A | A98G | T39A, E44D, V60I, T69TP, V118I, D121H, K122E, I142V, A158S, S162SN, Q174QK, D177E, E203K, Q207QE, H208Y, R211K, K223Q, L228H, A288S, I293V, P294Q, E297EK, K311R, G333GE, R356K, G359GS, K366R, T386I |
| >7152-30901| codons 1-399 PISPIETVPVKLKPGMDGPKVKQWPLTEEKIKALVEICAELEKDGKISKIGPENPYNTPI FAIKKKNSPRWRKLMDFRELNKRTQDFWEVQLGIPHPGGLKKKKSVTVLDVGDAYFSIPL HEDFRKYTAFTIPSINNETPGVRYQYNVLPQGWKGSPSIFQNSMTKILEPFRKKNPEIVI CQYVDDLYVASDLEIGQHRTKIKELREYLWKWGFYTPDEKHQQEPPFHWMGYELHPDKWT VQPIVLPEKDSWTVNDIQKLVGKLNWASQIYAGIKVKQLCKLLRGTKSLTEVVQLTKEAE LELAENREILREPVHGVYYDPSKDLIAEIQKQEQGQWTYQIYQEPFKNLKTGKYAKMRSA HTNDVRQLTEAVQKIATESIVIWGKIPKFKLPIQKETWE |
Protease Sequence
| PIMajorDRMs | PIMinorDRMs | Polys | UnusualMuts |
| V32I, M46I, I47V, I54L, L90M | L10F, G73T | I3IV, I15V, K20R, E35D, M36I, N37S, R57K, L63P, I64V, I93L |
| >7152-30901| codons 1-99 PQVTLWQRPFVTIKVGGQLREALLDTGADDTILEDISLPGRWKPKIVGGIGGFLKVKQYD QIPVEICGHKAITTVLVGPTPVNIIGRNLMTQLGCTLNF |
References
| Author | Title | Citation |
| Baxter, JD | Genotypic changes in human immunodeficiency virus type 1 protease associated with reduced susceptibility and virologic response to the protease inhibitor tipranavir. | J Virol, 2006 |