<!--#if expr="$title" --> <!--#echo var="title" --> <!--#else --> HIV Drug Resistance Database <!--#endif -->
Stanford University HIV Drug Resistance Database - A curated public database designed to represent, store, and analyze the divergent forms of data underlying HIV drug resistance.

Isolate Data

Patient Isolate Region Year Species Subtype Source Clone Method
48-7152 7152-30901 Spain 2003 HIV1 B Plasma None

Treatment History
Order Regimen Weeks
1 PI|NRTI|NNRTI NA

RT Sequence
NRTIMajorDRMs NRTIMinorDRMs NNRTIMajorDRMs NNRTIMinorDRMs Polys UnusualMuts
M41L, D67N, K70R, M184V, L210W, T215Y V75M, K219E Y181C, G190A A98G T39A, E44D, V60I, T69TP, V118I, D121H, K122E, I142V, A158S, S162SN, Q174QK, D177E, E203K, Q207QE, H208Y, R211K, K223Q, L228H, A288S, I293V, P294Q, E297EK, K311R, G333GE, R356K, G359GS, K366R, T386I  
>7152-30901| codons 1-399
PISPIETVPVKLKPGMDGPKVKQWPLTEEKIKALVEICAELEKDGKISKIGPENPYNTPI
FAIKKKNSPRWRKLMDFRELNKRTQDFWEVQLGIPHPGGLKKKKSVTVLDVGDAYFSIPL
HEDFRKYTAFTIPSINNETPGVRYQYNVLPQGWKGSPSIFQNSMTKILEPFRKKNPEIVI
CQYVDDLYVASDLEIGQHRTKIKELREYLWKWGFYTPDEKHQQEPPFHWMGYELHPDKWT
VQPIVLPEKDSWTVNDIQKLVGKLNWASQIYAGIKVKQLCKLLRGTKSLTEVVQLTKEAE
LELAENREILREPVHGVYYDPSKDLIAEIQKQEQGQWTYQIYQEPFKNLKTGKYAKMRSA
HTNDVRQLTEAVQKIATESIVIWGKIPKFKLPIQKETWE

Protease Sequence
PIMajorDRMs PIMinorDRMs Polys UnusualMuts
V32I, M46I, I47V, I54L, L90M L10F, G73T I3IV, I15V, K20R, E35D, M36I, N37S, R57K, L63P, I64V, I93L  
>7152-30901| codons 1-99
PQVTLWQRPFVTIKVGGQLREALLDTGADDTILEDISLPGRWKPKIVGGIGGFLKVKQYD
QIPVEICGHKAITTVLVGPTPVNIIGRNLMTQLGCTLNF

References
Author Title Citation
Baxter, JD Genotypic changes in human immunodeficiency virus type 1 protease associated with reduced susceptibility and virologic response to the protease inhibitor tipranavir. J Virol, 2006