Isolate Data
| Patient | Isolate | Region | Year | Species | Subtype | Source | Clone Method |
| 48-7151 | 7151-30825 | Spain | 2003 | HIV1 | B | Plasma | None |
Treatment History
| Order | Regimen | Weeks |
| 1 | PI|NRTI|NNRTI | NA |
RT Sequence
| NRTIMajorDRMs | NRTIMinorDRMs | NNRTIMajorDRMs | NNRTIMinorDRMs | Polys | UnusualMuts |
| M41L, T215DY | K103N | V108I | V35L, D123E, I135L, Q174N, D177E, V179I, G196GR, T200I, I257IL, A272P, E297A, Q334G, A371T, A376T, T386M |
| >7151-30825| codons 1-399 PISPIETVPVKLKPGMDGPKVKQWPLTEEKIKALLEICTELEKEGKISKIGPENPYNTPV FAIKKKDSTKWRKLVDFRELNKRTQDFWEVQLGIPHPAGLKKNKSVTILDVGDAYFSVPL DKEFRKYTAFTIPSLNNETPGIRYQYNVLPQGWKGSPAIFQSSMTKILEPFRKNNPEIII YQYMDDLYVGSDLEIRQHRIKIEELRQHLLRWGFYTPDKKHQKEPPFLWMGYELHPDKWT VQPIVLPEKDSWTVNDLQKLVGKLNWASQIYPGIKVKQLCKLLRGTKALTEVIPLTAEAE LELAENREILKEPVHGVYYDPSKDLIAEIQKQGGGQWTYQIYQEPFKNLKTGKYARMRGA HTNDVKQLTETVQKITTESIVIWGKMPKFKLPIQKETWE |
Protease Sequence
| PIMajorDRMs | PIMinorDRMs | Polys | UnusualMuts |
| D30N, L90M | F53L, N88D | I15IV, L19V, L63P, C67W, I93L | C95GV |
| >7151-30825| codons 1-99 PQITLWQRPLVTIKVGGQVKEALLDTGADNTVLEEMNLPGRWKPKMIGGIGGLIKVRQYD QIPIEIWGHKAIGTVLVGPTPVNIIGRDLMTQLGVTLNF |
References
| Author | Title | Citation |
| Baxter, JD | Genotypic changes in human immunodeficiency virus type 1 protease associated with reduced susceptibility and virologic response to the protease inhibitor tipranavir. | J Virol, 2006 |