Isolate Data
| Patient | Isolate | Region | Year | Species | Subtype | Source | Clone Method |
| 48-7150 | 7150-30825 | Spain | 2003 | HIV1 | B | Plasma | None |
Treatment History
| Order | Regimen | Weeks |
| 1 | PI|NRTI|NNRTI | NA |
RT Sequence
| NRTIMajorDRMs | NRTIMinorDRMs | NNRTIMajorDRMs | NNRTIMinorDRMs | Polys | UnusualMuts |
| M41L, L210W, T215Y | N348I | K103N | T39TA, K122E, E138A, A158S, E169D, Q174AE, I178M, V179I, A272P, V292I, I293V, K311R, Q334R, G335D, R358K |
| >7150-30825| codons 1-399 PISPIETVPVKLKPGMDGPKVKQWPLTEEKIKALVEICAELEKEGKISKIGPENPYNTPV FAIKKKDSTKWRKLVDFRELNKRTQDFWEVQLGIPHPAGLKKNKSVTVLDVGDAYFSVPL DEDFRKYTAFTIPSINNATPGIRYQYNVLPQGWKGSPSIFQSSMTKILDPFRKENPDMII YQYMDDLYVGSDLEIGQHRTKIEELRQHLWRWGFYTPDKKHQKEPPFLWMGYELHPDKWT VQPIVLPEKDSWTVNDIQKLVGKLNWASQIYPGIKVKQLCKLLRGTKALTEIVPLTEEAE LELAENREILREPVHGVYYDPSKDLIAEIQKQGRDQWTYQIYQEPFKILKTGKYARMKGA HTNDVKQLTEAVQKIATESIVIWGKTPKFKLPIQKETWE |
Protease Sequence
| PIMajorDRMs | PIMinorDRMs | Polys | UnusualMuts |
| V32I, M46I, I47V, V82CG, L90M | Q58E, G73C | L10I, I15V, L19Q, K20T, L63P, I64V, V77VI, I93L, C95F |
| >7150-30825| codons 1-99 PQITLWQRPIVTIKVGGQQTEALLDTGADDTILEEMNLPGRWKPKIVGGIGGFIKVREYD QIPVEICGHKAICTVLIGPTPGNIIGRNLMTQLGFTLNF |
References
| Author | Title | Citation |
| Baxter, JD | Genotypic changes in human immunodeficiency virus type 1 protease associated with reduced susceptibility and virologic response to the protease inhibitor tipranavir. | J Virol, 2006 |