Isolate Data
| Patient | Isolate | Region | Year | Species | Subtype | Source | Clone Method |
| 48-7149 | 7149-30709 | Spain | 2003 | HIV1 | B | Plasma | None |
Treatment History
| Order | Regimen | Weeks |
| 1 | PI|NRTI|NNRTI | NA |
Protease Sequence
| PIMajorDRMs | PIMinorDRMs | Polys | UnusualMuts |
| I54V, V82A, I84V | L24I, F53L | L10I, L19I, R41K, D60E, L63P, I66F, A71V, V77I |
| >7149-30709| codons 1-99 PQITLWQRPIVTIKIGGQIKEALIDTGADDTVLEEMNLPGKWKPKMIGGIGGLVKVRQYE QIPIEFCGHKVIGTVLIGPTPANVIGRNLLTQIGCTLNF |
RT Sequence
| NRTIMajorDRMs | NRTIMinorDRMs | NNRTIMajorDRMs | NNRTIMinorDRMs | Polys | UnusualMuts |
| M41L, D67N, T69D, K70R, L210W, T215Y | K219H | K103N, Y181C | K20R, V35L, T39A, E44D, V60I, V118I, K122E, S162C, I178L, V179I, G196E, Q197K, R211K, D218E, L228H, A272P, T286A, I293V, E297A, V317A, A360T, K366R, A371V, I375V, K395R |
| >7149-30709| codons 1-399 PISPIETVPVKLKPGMDGPRVKQWPLTEEKIKALLEICAELEKDGKISKIGPENPYNTPI FAIKKKNSDRWRKLVDFRELNKRTQDFWEVQLGIPHPAGLKKNKSVTVLDVGDAYFSIPL DEDFRKYTAFTIPSINNETPGIRYQYNVLPQGWKGSPAIFQCSMTKILEPFRKQNPDLII CQYMDDLYVGSDLEIEKHRTKIEELRQHLWKWGFYTPEHKHQKEPPFHWMGYELHPDKWT VQPIVLPEKDSWTVNDIQKLVGKLNWASQIYPGIKVKQLCKLLRGAKALTEVVPLTAEAE LELAENREILKEPVHGAYYDPSKDLIAEIQKQGQGQWTYQIYQEPFKNLKTGKYARMRGT HTNDVRQLTEVVQKVATESIVIWGKTPKFKLPIQRETWE |
References
| Author | Title | Citation |
| Baxter, JD | Genotypic changes in human immunodeficiency virus type 1 protease associated with reduced susceptibility and virologic response to the protease inhibitor tipranavir. | J Virol, 2006 |