Isolate Data
| Patient | Isolate | Region | Year | Species | Subtype | Source | Clone Method |
| 48-7146 | 7146-30610 | Spain | 2003 | HIV1 | B | Plasma | None |
Treatment History
| Order | Regimen | Weeks |
| 1 | PI|NRTI|NNRTI | NA |
RT Sequence
| NRTIMajorDRMs | NRTIMinorDRMs | NNRTIMajorDRMs | NNRTIMinorDRMs | Polys | UnusualMuts |
| M41L, D67N, L74V, L210W, T215Y | K219N | K103N, Y181C, G190A | F227L | P4S, V35L, V118I, D123E, I202V, H208Y, H221Y, K223E, A272P, R284K, T286A, E297K, I329L, R358K, G359S, V365I | W212S |
| >7146-30610| codons 1-399 PISSIETVPVKLKPGMDGPKVKQWPLTEEKIKALLEICTELEKEGKISKIGPENPYNTPV FAIKKKNSTKWRKVVDFRELNKRTQDFWEVQLGIPHPAGLKKNKSVTVLDVGDAYFSIPL DKEFRKYTAFTIPSINNETPGIRYQYNVLPQGWKGSPAIFQSSMTKILEPFRKQNPDIVI CQYMDDLYVASDLEIGQHRTKVEELRQYLWRSGFYTPDNKYQEEPPLLWMGYELHPDKWT VQPIVLPEKDSWTVNDIQKLVGKLNWASQIYPGIKVKQLCKLLKGAKALTEVIPLTKEAE LELAENREILKEPVHGVYYDPSKDLIAELQKQGQGQWTYQIYQEPFKNLKTGKYARMKSA HTNDIKQLTEAVQKIATESIVIWGKTPKFKLPIQKETWE |
Protease Sequence
| PIMajorDRMs | PIMinorDRMs | Polys | UnusualMuts |
| G48L, I54T, V82S | L10I, T12K, I13V, I15V, K20I, L63P, A71I, I72V, V77I, P79D, Q92R |
| >7146-30610| codons 1-99 PQITLWQRPIVKVKVGGQLIEALLDTGADDTVLEEMNLPGRWKPKMILGIGGFTKVRQYD QIPIEICGHKIVGTVLIGDTPSNIIGRNLLTRIGCTLNF |
References
| Author | Title | Citation |
| Baxter, JD | Genotypic changes in human immunodeficiency virus type 1 protease associated with reduced susceptibility and virologic response to the protease inhibitor tipranavir. | J Virol, 2006 |