Isolate Data
| Patient | Isolate | Region | Year | Species | Subtype | Source | Clone Method |
| 48-7145 | 7145-30602 | Spain | 2003 | HIV1 | B | Plasma | None |
Treatment History
| Order | Regimen | Weeks |
| 1 | PI|NRTI|NNRTI | NA |
Protease Sequence
| PIMajorDRMs | PIMinorDRMs | Polys | UnusualMuts |
| I54V, V82A | L24I, Q58E | L10I, M36I, I62V, L63Q, I64V, H69R |
| >7145-30602| codons 1-99 PQITLWQRPIVTIKIGGQLKEALIDTGADDTVLEEINLPGRWKPKMIGGIGGFVKVREYD QVQVEICGRKAIGTVLVGPTPANIIGRNLLTQIGCTLNF |
RT Sequence
| NRTIMajorDRMs | NRTIMinorDRMs | NNRTIMajorDRMs | NNRTIMinorDRMs | Polys | UnusualMuts |
| T215Y | Y188L | K122E, I135L, S162D, K166R, Q174H, G196E, R211K, A272P, I293V, E297A, Q334D, P345T, A360T, K366R, T369I, A371V, A376S, T386I |
| >7145-30602| codons 1-399 PISPIETVPVKLKPGMDGPKVKQWPLTEEKIKALVEICTEMEKEGKISKIGPENPYNTPV FAIKKKDSTKWRKLVDFRELNKRTQDFWEVQLGIPHPAGLKKKKSVTVLDVGDAYFSVPL DEDFRKYTAFTIPSLNNETPGIRYQYNVLPQGWKGSPAIFQDSMTRILEPFRKHNPDIVI YQYMDDLLVGSDLEIEQHRTKIEELRQHLLKWGFYTPDKKHQKEPPFLWMGYELHPDKWT VQPIVLPEKDSWTVNDIQKLVGKLNWASQIYPGIKVKQLCKLLRGTKALTEVVPLTAEAE LELAENREILKEPVHGVYYDPSKDLIAEIQKQGDGQWTYQIYQETFKNLKTGKYARMRGT HTNDVRQLIEVVQKISTESIVIWGKIPKFKLPIQKETWE |
References
| Author | Title | Citation |
| Baxter, JD | Genotypic changes in human immunodeficiency virus type 1 protease associated with reduced susceptibility and virologic response to the protease inhibitor tipranavir. | J Virol, 2006 |