Isolate Data
| Patient | Isolate | Region | Year | Species | Subtype | Source | Clone Method |
| 48-7142 | 7142-30731 | Spain | 2003 | HIV1 | B | Plasma | None |
Treatment History
| Order | Regimen | Weeks |
| 1 | PI|NRTI|NNRTI | NA |
Protease Sequence
| PIMajorDRMs | PIMinorDRMs | Polys | UnusualMuts |
| M46L, G48V, I54V, V82C, I84V, L90M | L33F, Q58E | L10I, G16GAE, N37C, I62V, L63PS, A71V, I72IK, I93L |
| >7142-30731| codons 1-99 PQITLWQRPIVTIKIEGQLKEALLDTGADDTVFEEMCLPGRWKPKLIVGIGGFVKVREYD QVSIEICGHKVKGTVLVGPTPCNVIGRNLMTQLGCTLNF |
RT Sequence
| NRTIMajorDRMs | NRTIMinorDRMs | NNRTIMajorDRMs | NNRTIMinorDRMs | Polys | UnusualMuts |
| M41L, K70R, V75T, L210W, T215Y | A62V, D67S, K219DE | S68G, V118VI, K122E, I142V, S162A, D177E, I178IM, E203A, H208HY, A272P, T286A, E297K, I326IV, Q334H, G335D, R356K, G359S, T369V, A371AV, T377TI |
| >7142-30731| codons 1-399 PISPIETVPVKLKPGMDGPKVKQWPLTEEKIKALVEICTELEKEGKISKIGPENPYNTPV FVIKKKSGTRWRKLTDFRELNKRTQDFWEVQLGIPHPAGLKKKKSVTVLDVGDAYFSIPL DEDFRKYTAFTIPSINNETPGVRYQYNVLPQGWKGSPAIFQASMTKILEPFRKQNPEMVI YQYMDDLYVGSDLEIGQHRTKIAELRQYLWRWGFYTPDEKHQKEPPFLWMGYELHPDKWT VQPIVLPEKDSWTVNDIQKLVGKLNWASQIYPGIKVKQLCKLLRGAKALTEVIPLTKEAE LELAENREILKEPVHGVYYDPSKDLVAEIQKQGHDQWTYQIYQEPFKNLKTGKYAKMRSA HTNDVKQLVEVVQKIAIESIVIWGKTPKFKLPIQKETWE |
References
| Author | Title | Citation |
| Baxter, JD | Genotypic changes in human immunodeficiency virus type 1 protease associated with reduced susceptibility and virologic response to the protease inhibitor tipranavir. | J Virol, 2006 |