<!--#if expr="$title" --> <!--#echo var="title" --> <!--#else --> HIV Drug Resistance Database <!--#endif -->
Stanford University HIV Drug Resistance Database - A curated public database designed to represent, store, and analyze the divergent forms of data underlying HIV drug resistance.

Isolate Data

Patient Isolate Region Year Species Subtype Source Clone Method
48-7142 7142-30731 Spain 2003 HIV1 B Plasma None

Treatment History
Order Regimen Weeks
1 PI|NRTI|NNRTI NA

Protease Sequence
PIMajorDRMs PIMinorDRMs Polys UnusualMuts
M46L, G48V, I54V, V82C, I84V, L90M L33F, Q58E L10I, G16GAE, N37C, I62V, L63PS, A71V, I72IK, I93L  
>7142-30731| codons 1-99
PQITLWQRPIVTIKIEGQLKEALLDTGADDTVFEEMCLPGRWKPKLIVGIGGFVKVREYD
QVSIEICGHKVKGTVLVGPTPCNVIGRNLMTQLGCTLNF

RT Sequence
NRTIMajorDRMs NRTIMinorDRMs NNRTIMajorDRMs NNRTIMinorDRMs Polys UnusualMuts
M41L, K70R, L210W, T215Y A62V, D67S, V75T, K219DE     S68G, V118VI, K122E, I142V, S162A, D177E, I178IM, E203A, H208HY, A272P, T286A, E297K, I326IV, Q334H, G335D, R356K, G359S, T369V, A371AV, T377TI  
>7142-30731| codons 1-399
PISPIETVPVKLKPGMDGPKVKQWPLTEEKIKALVEICTELEKEGKISKIGPENPYNTPV
FVIKKKSGTRWRKLTDFRELNKRTQDFWEVQLGIPHPAGLKKKKSVTVLDVGDAYFSIPL
DEDFRKYTAFTIPSINNETPGVRYQYNVLPQGWKGSPAIFQASMTKILEPFRKQNPEMVI
YQYMDDLYVGSDLEIGQHRTKIAELRQYLWRWGFYTPDEKHQKEPPFLWMGYELHPDKWT
VQPIVLPEKDSWTVNDIQKLVGKLNWASQIYPGIKVKQLCKLLRGAKALTEVIPLTKEAE
LELAENREILKEPVHGVYYDPSKDLVAEIQKQGHDQWTYQIYQEPFKNLKTGKYAKMRSA
HTNDVKQLVEVVQKIAIESIVIWGKTPKFKLPIQKETWE

References
Author Title Citation
Baxter, JD Genotypic changes in human immunodeficiency virus type 1 protease associated with reduced susceptibility and virologic response to the protease inhibitor tipranavir. J Virol, 2006