Isolate Data
| Patient | Isolate | Region | Year | Species | Subtype | Source | Clone Method |
| 48-7139 | 7139-30730 | Spain | 2003 | HIV1 | B | Plasma | None |
Treatment History
| Order | Regimen | Weeks |
| 1 | PI|NRTI|NNRTI | NA |
Protease Sequence
| PIMajorDRMs | PIMinorDRMs | Polys | UnusualMuts |
| V32I, M46IV, I47V, I54L, V82VA, L90M | L33F, K43T | L10I, K20R, E35D, M36I, N37D, I62V, L63P, A71V, I85V, Q92K |
| >7139-30730| codons 1-99 PQITLWQRPIVTIKIGGQLREALLDTGADDTIFEDIDLPGRWTPKVVGGIGGFLKVRQYD QVPIEICGHKVIGTVLVGPTPANIVGRNLMTKIGCTLNF |
RT Sequence
| NRTIMajorDRMs | NRTIMinorDRMs | NNRTIMajorDRMs | NNRTIMinorDRMs | Polys | UnusualMuts |
| D67N, K70R, Q151M | F116Y, T215I, K219Q | K101E, G190A | I2IV, P4PST, K20KR, V35T, T39A, V60I, T69N, K103KR, V111VIM, K122E, I135T, E169D, P170L, L228LR, A272S, T286A, V317VA, I326V, M357T, T386I |
| >7139-30730| codons 1-399 PVSTIETVPVKLKPGMDGPRVKQWPLTEEKIKALTEICAEMEKEGKISKIGPENPYNTPI FAIKKKNSNRWRKLVDFRELNKRTQDFWEVQLGIPHPAGLEKRKSVTVLDMGDAYYSVPL DEDFRKYTAFTIPSTNNETPGIRYQYNVLPMGWKGSPAIFQSSMTKILDLFRKQNPDIVI YQYMDDLYVASDLEIGQHRTKIEELRQHLLRWGFITPDQKHQKEPPFRWMGYELHPDKWT VQPIVLPEKDSWTVNDIQKLVGKLNWASQIYSGIKVKQLCKLLRGAKALTEVIPLTEEAE LELAENREILKEPVHGAYYDPSKDLVAEIQKQGQGQWTYQIYQEPFKNLKTGKYARTRGA HTNDVKQLTEAVQKIATESIVIWGKIPKFKLPIQKETWE |
References
| Author | Title | Citation |
| Baxter, JD | Genotypic changes in human immunodeficiency virus type 1 protease associated with reduced susceptibility and virologic response to the protease inhibitor tipranavir. | J Virol, 2006 |