<!--#if expr="$title" --> <!--#echo var="title" --> <!--#else --> HIV Drug Resistance Database <!--#endif -->
Stanford University HIV Drug Resistance Database - A curated public database designed to represent, store, and analyze the divergent forms of data underlying HIV drug resistance.

Isolate Data

Patient Isolate Region Year Species Subtype Source Clone Method
48-7137 7137-30724 Spain 2003 HIV1 B Plasma None

Treatment History
Order Regimen Weeks
1 PI|NRTI|NNRTI NA

RT Sequence
NRTIMajorDRMs NRTIMinorDRMs NNRTIMajorDRMs NNRTIMinorDRMs Polys UnusualMuts
M41ML, K70R, T215F D67G, K219E Y181YC, G190A V179VD, K238KT T39TI, V60VI, S68G, K101KQ, K102KR, D121Y, K122E, D177E, Q207EG, R211K, L228H, A272P, K277R, K281KR, I293V, E297K, I329V, G359GS, A371V, A376S, T377L  
>7137-30724| codons 1-400
PISPIETVPVKLKPGMDGPKVKQWPLTEEKIKALVEICIELEKEGKISKIGPENPYNTPI
FAIKKKGGTRWRKLVDFRELNKRTQDFWEVQLGIPHPAGLQRKKSVTVLDVGDAYFSVPL
YEDFRKYTAFTIPSINNETPGIRYQYNVLPQGWKGSPAIFQSSMTKILEPFRKQNPEIDI
CQYMDDLYVASDLEIGQHRTKIEELRGHLLKWGFFTPDEKHQKEPPFHWMGYELHPDTWT
VQPIVLPEKDSWTVNDIQKLVGKLNWASQIYPGIKVRQLCRLLRGTKALTEVVPLTKEAE
LELAENREILKEPVHGVYYDPSKDLIAEVQKQGQGQWTYQIYQEPFKNLKTGKYARMRSA
HTNDVKQLTEVVQKISLESIVIWGKTPKFKLPIQKETWEA

Protease Sequence
PIMajorDRMs PIMinorDRMs Polys UnusualMuts
I54V, I84V, L90M L10F, L33F, G73S I62V, L63P, I66IL, C67W, A71V, I72L, I93L  
>7137-30724| codons 1-99
PQITLWQRPFVTIKIGGQLKEALLDTGADDTVFEEMNLPGRWKPKMIGGIGGFVKVRQYD
QVPIELWGHKVLSTVLVGPTPVNVIGRNLMTQLGCTLNF

References
Author Title Citation
Baxter, JD Genotypic changes in human immunodeficiency virus type 1 protease associated with reduced susceptibility and virologic response to the protease inhibitor tipranavir. J Virol, 2006