Isolate Data
| Patient | Isolate | Region | Year | Species | Subtype | Source | Clone Method |
| 48-7137 | 7137-30724 | Spain | 2003 | HIV1 | B | Plasma | None |
Treatment History
| Order | Regimen | Weeks |
| 1 | PI|NRTI|NNRTI | NA |
Protease Sequence
| PIMajorDRMs | PIMinorDRMs | Polys | UnusualMuts |
| I54V, I84V, L90M | L10F, L33F, G73S | I62V, L63P, I66IL, C67W, A71V, I72L, I93L |
| >7137-30724| codons 1-99 PQITLWQRPFVTIKIGGQLKEALLDTGADDTVFEEMNLPGRWKPKMIGGIGGFVKVRQYD QVPIELWGHKVLSTVLVGPTPVNVIGRNLMTQLGCTLNF |
RT Sequence
| NRTIMajorDRMs | NRTIMinorDRMs | NNRTIMajorDRMs | NNRTIMinorDRMs | Polys | UnusualMuts |
| M41ML, K70R, T215F | D67G, K219E | Y181YC, G190A | V179VD, K238KT | T39TI, V60VI, S68G, K101KQ, K102KR, D121Y, K122E, D177E, Q207EG, R211K, L228H, A272P, K277R, K281KR, I293V, E297K, I329V, G359GS, A371V, A376S, T377L |
| >7137-30724| codons 1-400 PISPIETVPVKLKPGMDGPKVKQWPLTEEKIKALVEICIELEKEGKISKIGPENPYNTPI FAIKKKGGTRWRKLVDFRELNKRTQDFWEVQLGIPHPAGLQRKKSVTVLDVGDAYFSVPL YEDFRKYTAFTIPSINNETPGIRYQYNVLPQGWKGSPAIFQSSMTKILEPFRKQNPEIDI CQYMDDLYVASDLEIGQHRTKIEELRGHLLKWGFFTPDEKHQKEPPFHWMGYELHPDTWT VQPIVLPEKDSWTVNDIQKLVGKLNWASQIYPGIKVRQLCRLLRGTKALTEVVPLTKEAE LELAENREILKEPVHGVYYDPSKDLIAEVQKQGQGQWTYQIYQEPFKNLKTGKYARMRSA HTNDVKQLTEVVQKISLESIVIWGKTPKFKLPIQKETWEA |
References
| Author | Title | Citation |
| Baxter, JD | Genotypic changes in human immunodeficiency virus type 1 protease associated with reduced susceptibility and virologic response to the protease inhibitor tipranavir. | J Virol, 2006 |