<!--#if expr="$title" --> <!--#echo var="title" --> <!--#else --> HIV Drug Resistance Database <!--#endif -->
Stanford University HIV Drug Resistance Database - A curated public database designed to represent, store, and analyze the divergent forms of data underlying HIV drug resistance.

Isolate Data

Patient Isolate Region Year Species Subtype Source Clone Method
48-7136 7136-30721 Spain 2003 HIV1 B Plasma None

Treatment History
Order Regimen Weeks
1 PI|NRTI|NNRTI NA

RT Sequence
NRTIMajorDRMs NRTIMinorDRMs NNRTIMajorDRMs NNRTIMinorDRMs Polys UnusualMuts
M41L, L74V, M184V, L210W, T215Y D67G, K219N K103N, Y181C A98G, V179F E6K, K11KR, K20R, K32KT, T39K, E40X, K43E, E44ED, S68G, K101R, V118I, K122E, Q197E, T200A, E203K, Q207D, H208Y, R211K, K223E, L228H, T286A, T296S, K311R, D324E, I326V, I329V, M357T, R358K  
>7136-30721| codons 1-399
PISPIKTVPVRLKPGMDGPRVKQWPLTEEKITALVEICKXLEEDGKISKIGPENPYNTPV
FAIKKKGGTKWRKVVDFRELNKRTQDFWEVQLGIPHPGGLRKNKSVTVLDVGDAYFSIPL
DEDFRKYTAFTIPSINNETPGIRYQYNVLPQGWKGSPAIFQSSMTKILEPFRKQNPDIFI
CQYVDDLYVGSDLEIGEHRAKIKELRDYLWKWGFYTPDNKHQEEPPFHWMGYELHPDKWT
VQPIVLPEKDSWTVNDIQKLVGKLNWASQIYAGIKVKQLCKLLRGAKALTEVIPLSEEAE
LELAENREILREPVHGVYYDPSKELVAEVQKQGQGQWTYQIYQEPFKNLKTGKYARTKGA
HTNDVKQLTEAVQKIATESIVIWGKTPKFKLPIQKETWE

Protease Sequence
PIMajorDRMs PIMinorDRMs Polys UnusualMuts
M46I, I54V, V82A, L90M L33F, G73S L10I, K20R, E35D, M36I, N37Q, R41K, R57RK, I62V, L63P, A71V, I72T, I93L  
>7136-30721| codons 1-99
PQITLWQRPIVTIKIGGQLREALLDTGADDTVFEDIQLPGKWKPKIIGGIGGFVKVKQYD
QVPIEICGHKVTSTVLVGPTPANIIGRNLMTQLGCTLNF

References
Author Title Citation
Baxter, JD Genotypic changes in human immunodeficiency virus type 1 protease associated with reduced susceptibility and virologic response to the protease inhibitor tipranavir. J Virol, 2006