Isolate Data
| Patient | Isolate | Region | Year | Species | Subtype | Source | Clone Method |
| 48-7136 | 7136-30721 | Spain | 2003 | HIV1 | B | Plasma | None |
Treatment History
| Order | Regimen | Weeks |
| 1 | PI|NRTI|NNRTI | NA |
Protease Sequence
| PIMajorDRMs | PIMinorDRMs | Polys | UnusualMuts |
| M46I, I54V, V82A, L90M | L33F, G73S | L10I, K20R, E35D, M36I, N37Q, R41K, R57RK, I62V, L63P, A71V, I72T, I93L |
| >7136-30721| codons 1-99 PQITLWQRPIVTIKIGGQLREALLDTGADDTVFEDIQLPGKWKPKIIGGIGGFVKVKQYD QVPIEICGHKVTSTVLVGPTPANIIGRNLMTQLGCTLNF |
RT Sequence
| NRTIMajorDRMs | NRTIMinorDRMs | NNRTIMajorDRMs | NNRTIMinorDRMs | Polys | UnusualMuts |
| M41L, L74V, M184V, L210W, T215Y | D67G, K219N | K103N, Y181C | A98G, V179F | E6K, K11KR, K20R, K32KT, T39K, E40X, K43E, E44ED, S68G, K101R, V118I, K122E, Q197E, T200A, E203K, Q207D, H208Y, R211K, K223E, L228H, T286A, T296S, K311R, D324E, I326V, I329V, M357T, R358K |
| >7136-30721| codons 1-399 PISPIKTVPVRLKPGMDGPRVKQWPLTEEKITALVEICKXLEEDGKISKIGPENPYNTPV FAIKKKGGTKWRKVVDFRELNKRTQDFWEVQLGIPHPGGLRKNKSVTVLDVGDAYFSIPL DEDFRKYTAFTIPSINNETPGIRYQYNVLPQGWKGSPAIFQSSMTKILEPFRKQNPDIFI CQYVDDLYVGSDLEIGEHRAKIKELRDYLWKWGFYTPDNKHQEEPPFHWMGYELHPDKWT VQPIVLPEKDSWTVNDIQKLVGKLNWASQIYAGIKVKQLCKLLRGAKALTEVIPLSEEAE LELAENREILREPVHGVYYDPSKELVAEVQKQGQGQWTYQIYQEPFKNLKTGKYARTKGA HTNDVKQLTEAVQKIATESIVIWGKTPKFKLPIQKETWE |
References
| Author | Title | Citation |
| Baxter, JD | Genotypic changes in human immunodeficiency virus type 1 protease associated with reduced susceptibility and virologic response to the protease inhibitor tipranavir. | J Virol, 2006 |