<!--#if expr="$title" --> <!--#echo var="title" --> <!--#else --> HIV Drug Resistance Database <!--#endif -->
Stanford University HIV Drug Resistance Database - A curated public database designed to represent, store, and analyze the divergent forms of data underlying HIV drug resistance.

Isolate Data

Patient Isolate Region Year Species Subtype Source Clone Method
48-7135 7135-30716 Spain 2003 HIV1 B Plasma None

Treatment History
Order Regimen Weeks
1 PI|NRTI|NNRTI NA

RT Sequence
NRTIMajorDRMs NRTIMinorDRMs NNRTIMajorDRMs NNRTIMinorDRMs Polys UnusualMuts
M41L, D67N, T69D, K70R, L74I, T215F K219Q, N348I K101E, Y181C, G190A V108I P4S, V35M, T39A, A98S, K122E, I135V, I142V, S162C, S163A, Q197E, Q207E, R211K, D218E, H221Y, L228H, A272P, K277R, L283LI, I293V, E297A, Q334L, G359GS, A376T, T386I, K390R  
>7135-30716| codons 1-399
PISSIETVPVKLKPGMDGPKVKQWPLTEEKIKALMEICAELEKEGKISKIGPENPYNTPV
FAIKKKNSDRWRKIVDFRELNKRTQDFWEVQLGIPHPSGLEKKKSVTILDVGDAYFSVPL
DEDFRKYTAFTIPSVNNETPGVRYQYNVLPQGWKGSPAIFQCAMTKILEPFRKQNPDIVI
CQYMDDLYVASDLEIGEHRTKIEELREHLLKWGFFTPEQKYQKEPPFHWMGYELHPDKWT
VQPIVLPEKDSWTVNDIQKLVGKLNWASQIYPGIKVRQLCKLIRGTKALTEVVPLTAEAE
LELAENREILKEPVHGVYYDPSKDLIAEIQKQGLGQWTYQIYQEPFKILKTGKYARMRSA
HTNDVKQLTEAVQKITTESIVIWGKIPKFRLPIQKETWE

Protease Sequence
PIMajorDRMs PIMinorDRMs Polys UnusualMuts
G48V, I54V, V82S L24I L10I, K14KR, L19T, K20R, E35D, M36I, N37D, R57K, I62V, L63P, A71V, I72V, T74S, V77I, I93L  
>7135-30716| codons 1-99
PQITLWQRPIVTIRIGGQTREALIDTGADDTVLEDIDLPGRWKPKMIVGIGGFVKVKQYD
QVPIEICGHKVVGSVLIGPTPSNIIGRNLLTQLGCTLNF

References
Author Title Citation
Baxter, JD Genotypic changes in human immunodeficiency virus type 1 protease associated with reduced susceptibility and virologic response to the protease inhibitor tipranavir. J Virol, 2006