Isolate Data
| Patient | Isolate | Region | Year | Species | Subtype | Source | Clone Method |
| 48-7135 | 7135-30716 | Spain | 2003 | HIV1 | B | Plasma | None |
Treatment History
| Order | Regimen | Weeks |
| 1 | PI|NRTI|NNRTI | NA |
Protease Sequence
| PIMajorDRMs | PIMinorDRMs | Polys | UnusualMuts |
| G48V, I54V, V82S | L24I | L10I, K14KR, L19T, K20R, E35D, M36I, N37D, R57K, I62V, L63P, A71V, I72V, T74S, V77I, I93L |
| >7135-30716| codons 1-99 PQITLWQRPIVTIRIGGQTREALIDTGADDTVLEDIDLPGRWKPKMIVGIGGFVKVKQYD QVPIEICGHKVVGSVLIGPTPSNIIGRNLLTQLGCTLNF |
RT Sequence
| NRTIMajorDRMs | NRTIMinorDRMs | NNRTIMajorDRMs | NNRTIMinorDRMs | Polys | UnusualMuts |
| M41L, D67N, T69D, K70R, L74I, T215F | K219Q, N348I | K101E, Y181C, G190A | V108I | P4S, V35M, T39A, A98S, K122E, I135V, I142V, S162C, S163A, Q197E, Q207E, R211K, D218E, H221Y, L228H, A272P, K277R, L283LI, I293V, E297A, Q334L, G359GS, A376T, T386I, K390R |
| >7135-30716| codons 1-399 PISSIETVPVKLKPGMDGPKVKQWPLTEEKIKALMEICAELEKEGKISKIGPENPYNTPV FAIKKKNSDRWRKIVDFRELNKRTQDFWEVQLGIPHPSGLEKKKSVTILDVGDAYFSVPL DEDFRKYTAFTIPSVNNETPGVRYQYNVLPQGWKGSPAIFQCAMTKILEPFRKQNPDIVI CQYMDDLYVASDLEIGEHRTKIEELREHLLKWGFFTPEQKYQKEPPFHWMGYELHPDKWT VQPIVLPEKDSWTVNDIQKLVGKLNWASQIYPGIKVRQLCKLIRGTKALTEVVPLTAEAE LELAENREILKEPVHGVYYDPSKDLIAEIQKQGLGQWTYQIYQEPFKILKTGKYARMRSA HTNDVKQLTEAVQKITTESIVIWGKIPKFRLPIQKETWE |
References
| Author | Title | Citation |
| Baxter, JD | Genotypic changes in human immunodeficiency virus type 1 protease associated with reduced susceptibility and virologic response to the protease inhibitor tipranavir. | J Virol, 2006 |