Isolate Data
| Patient | Isolate | Region | Year | Species | Subtype | Source | Clone Method |
| 48-7133 | 7133-30722 | Spain | 2003 | HIV1 | B | Plasma | None |
Treatment History
| Order | Regimen | Weeks |
| 1 | PI|NRTI|NNRTI | NA |
RT Sequence
| NRTIMajorDRMs | NRTIMinorDRMs | NNRTIMajorDRMs | NNRTIMinorDRMs | Polys | UnusualMuts |
| M41L, D67N, L74V, L210W, T215Y | K219N | K101E, K103HN, Y181C, G190A | E28K, K32E, V35I, T39A, K43Q, E44D, V118I, K122P, D123E, I135T, D177E, Q207DE, H208Y, R211K, K238S, A272P, K277R, V292I, I293IV, E297K, M357V, V365VI, K395R, E399D |
| >7133-30722| codons 1-399 PISPIETVPVKLKPGMDGPKVKQWPLTKEKIEALIEICAELEQDGKISKIGPENPYNTPV FAIKKKNSTKWRKVVDFRELNKRTQDFWEVQLGIPHPAGLEKNKSVTVLDVGDAYFSIPL DPEFRKYTAFTIPSTNNETPGIRYQYNVLPQGWKGSPAIFQSSMTKILEPFRKQNPEIVI CQYMDDLYVASDLEIGQHRTKIEELREYLWKWGFYTPDNKHQKEPPFLWMGYELHPDSWT VQPIVLPEKDSWTVNDIQKLVGKLNWASQIYPGIKVRQLCKLLRGTKALTEIVPLTKEAE LELAENREILKEPVHGVYYDPSKDLIAEIQKQGQGQWTYQIYQEPFKNLKTGKYARVRGA HTNDIKQLTEAVQKIATESIVIWGKTPKFKLPIQRETWD |
Protease Sequence
| PIMajorDRMs | PIMinorDRMs | Polys | UnusualMuts |
| I54V, V82A, L90M | K43KT | L10I, K14KR, I15V, D60DE, I62IV, L63P, A71V |
| >7133-30722| codons 1-99 PQITLWQRPIVTIRVGGQLKEALLDTGADDTVLEEMNLPGRWTPKMIGGIGGFVKVRQYE QVPIEICGHKVIGTVLVGPTPANIIGRNLMTQIGCTLNF |
References
| Author | Title | Citation |
| Baxter, JD | Genotypic changes in human immunodeficiency virus type 1 protease associated with reduced susceptibility and virologic response to the protease inhibitor tipranavir. | J Virol, 2006 |