Isolate Data
| Patient | Isolate | Region | Year | Species | Subtype | Source | Clone Method |
| 48-7126 | 7126-30904 | Spain | 2003 | HIV1 | B | Plasma | None |
Treatment History
| Order | Regimen | Weeks |
| 1 | PI|NRTI|NNRTI | NA |
RT Sequence
| NRTIMajorDRMs | NRTIMinorDRMs | NNRTIMajorDRMs | NNRTIMinorDRMs | Polys | UnusualMuts |
| M41ML, L210LW | T215D, N348I | T39TA, K122KE, K166KR, G196GEKR, Q207QE, R211RK, V276VI, K277KR, L283LI, I293V, I326V, I341F, K366R, A371V, I375AV, K390KR |
| >7126-30904| codons 1-400 PISPIETVPVKLKPGMDGPKVKQWPLTEEKIKALVEICAELEKEGKISKIGPENPYNTPV FAIKKKDSTKWRKLVDFRELNKRTQDFWEVQLGIPHPAGLKKKKSVTVLDVGDAYFSVPL DEDFRKYTAFTIPSINNETPGIRYQYNVLPQGWKGSPAIFQSSMTRILEPFRKQNPDIVI YQYMDDLYVGSDLEIRQHRTKIEELREHLWKWGFDTPDKKHQKEPPFLWMGYELHPDKWT VQPIVLPEKDSWTVNDIQKLVGKLNWASQIYAGIKIRQLCKLIRGTKALTEVVPLTEEAE LELAENREILKEPVHGVYYDPSKDLVAEIQKQGQGQWTYQFYQEPFKILKTGKYARMRGA HTNDVRQLTEVVQKVATESIVIWGKTPKFRLPIQKETWEA |
Protease Sequence
| PIMajorDRMs | PIMinorDRMs | Polys | UnusualMuts |
| I84IV, L90M | L10LI, K20KR, N37AT, D60E, I62V, L63LP, A71AV, V77I, I93IL |
| >7126-30904| codons 1-99 PQITLWQRPIVTIKIGGQLREALLDTGADDTVLEEMTLPGRWKPKMIGGIGGFIKVRQYE QVPIEICGHKVIGTVLIGPTPVNVIGRNLMTQLGCTLNF |
References
| Author | Title | Citation |
| Baxter, JD | Genotypic changes in human immunodeficiency virus type 1 protease associated with reduced susceptibility and virologic response to the protease inhibitor tipranavir. | J Virol, 2006 |