<!--#if expr="$title" --> <!--#echo var="title" --> <!--#else --> HIV Drug Resistance Database <!--#endif -->
Stanford University HIV Drug Resistance Database - A curated public database designed to represent, store, and analyze the divergent forms of data underlying HIV drug resistance.

Isolate Data

Patient Isolate Region Year Species Subtype Source Clone Method
48-7125 7125-30902 Spain 2003 HIV1 B Plasma None

Treatment History
Order Regimen Weeks
1 PI|NRTI|NNRTI NA

Protease Sequence
PIMajorDRMs PIMinorDRMs Polys UnusualMuts
M46L, N88S L33LF L10I, T12TK, I13V, K14KR, I15V, K20I, R41K, L63P, A71T, I93L  
>7125-30902| codons 1-99
PQITLWQRPIVKVRVGGQLIEALLDTGADDTVFEEMNLPGKWKPKLIGGIGGFIKVRQYD
QIPIEICGHKTIGTVLVGPTPVNIIGRSLLTQLGCTLNF

RT Sequence
NRTIMajorDRMs NRTIMinorDRMs NNRTIMajorDRMs NNRTIMinorDRMs Polys UnusualMuts
M41L, D67N, L210W, T215Y V75I, K219N K103N V108I, K238T V35I, T39A, E44D, V118I, K122E, I132L, S162C, T200A, I202V, E203K, H208Y, R211K, K223E, L228R, E291D, I326V, A327AT, R356K, G359S, S379C  
>7125-30902| codons 1-399
PISPIETVPVKLKPGMDGPKVKQWPLTEEKIKALIEICAELEKDGKISKIGPENPYNTPV
FAIKKKNSTKWRKLIDFRELNKRTQDFWEVQLGIPHPAGLKKNKSVTILDVGDAYFSIPL
DEDFRKYTAFTLPSINNETPGIRYQYNVLPQGWKGSPAIFQCSMTKILEPFRKQNPDIVI
YQYMDDLYVGSDLEIGQHRAKVKELRQYLWKWGFYTPDNKHQEEPPFRWMGYELHPDTWT
VQPIVLPEKDSWTVNDIQKLVGKLNWASQIYAGIKVKQLCKLLRGTKALTDVIPLTEEAE
LELAENREILKEPVHGVYYDPSKDLVTEIQKQGQGQWTYQIYQEPFKNLKTGKYAKMRSA
HTNDVKQLTEAVQKIATECIVIWGKTPKFKLPIQKETWE

References
Author Title Citation
Baxter, JD Genotypic changes in human immunodeficiency virus type 1 protease associated with reduced susceptibility and virologic response to the protease inhibitor tipranavir. J Virol, 2006