Isolate Data
| Patient | Isolate | Region | Year | Species | Subtype | Source | Clone Method |
| 48-7125 | 7125-30902 | Spain | 2003 | HIV1 | B | Plasma | None |
Treatment History
| Order | Regimen | Weeks |
| 1 | PI|NRTI|NNRTI | NA |
Protease Sequence
| PIMajorDRMs | PIMinorDRMs | Polys | UnusualMuts |
| M46L, N88S | L33LF | L10I, T12TK, I13V, K14KR, I15V, K20I, R41K, L63P, A71T, I93L |
| >7125-30902| codons 1-99 PQITLWQRPIVKVRVGGQLIEALLDTGADDTVFEEMNLPGKWKPKLIGGIGGFIKVRQYD QIPIEICGHKTIGTVLVGPTPVNIIGRSLLTQLGCTLNF |
RT Sequence
| NRTIMajorDRMs | NRTIMinorDRMs | NNRTIMajorDRMs | NNRTIMinorDRMs | Polys | UnusualMuts |
| M41L, D67N, L210W, T215Y | V75I, K219N | K103N | V108I, K238T | V35I, T39A, E44D, V118I, K122E, I132L, S162C, T200A, I202V, E203K, H208Y, R211K, K223E, L228R, E291D, I326V, A327AT, R356K, G359S, S379C |
| >7125-30902| codons 1-399 PISPIETVPVKLKPGMDGPKVKQWPLTEEKIKALIEICAELEKDGKISKIGPENPYNTPV FAIKKKNSTKWRKLIDFRELNKRTQDFWEVQLGIPHPAGLKKNKSVTILDVGDAYFSIPL DEDFRKYTAFTLPSINNETPGIRYQYNVLPQGWKGSPAIFQCSMTKILEPFRKQNPDIVI YQYMDDLYVGSDLEIGQHRAKVKELRQYLWKWGFYTPDNKHQEEPPFRWMGYELHPDTWT VQPIVLPEKDSWTVNDIQKLVGKLNWASQIYAGIKVKQLCKLLRGTKALTDVIPLTEEAE LELAENREILKEPVHGVYYDPSKDLVTEIQKQGQGQWTYQIYQEPFKNLKTGKYAKMRSA HTNDVKQLTEAVQKIATECIVIWGKTPKFKLPIQKETWE |
References
| Author | Title | Citation |
| Baxter, JD | Genotypic changes in human immunodeficiency virus type 1 protease associated with reduced susceptibility and virologic response to the protease inhibitor tipranavir. | J Virol, 2006 |