<!--#if expr="$title" --> <!--#echo var="title" --> <!--#else --> HIV Drug Resistance Database <!--#endif -->
Stanford University HIV Drug Resistance Database - A curated public database designed to represent, store, and analyze the divergent forms of data underlying HIV drug resistance.

Isolate Data

Patient Isolate Region Year Species Subtype Source Clone Method
48-7124 7124-30902 Spain 2003 HIV1 CRF02_AG Plasma None

Treatment History
Order Regimen Weeks
1 PI|NRTI|NNRTI NA

Protease Sequence
PIMajorDRMs PIMinorDRMs Polys UnusualMuts
M46I, I47V, L76V, I84V Q58E L10I, I13A, K14IR, L19P, K20I, M36I, N37D, R41K, K55KR, L63P, H69K, K70R, L89I  
>7124-30902| codons 1-99
PQITLWQRPIVTARIGGQPIEALLDTGADDTVLEEIDLPGKWKPKIVGGIGGFIRVREYD
QIPIEICGKRAIGTVVVGPTPVNVIGRNILTQIGCTLNF

RT Sequence
NRTIMajorDRMs NRTIMinorDRMs NNRTIMajorDRMs NNRTIMinorDRMs Polys UnusualMuts
M41L, M184V, L210W, T215Y D67DE     M16V, V35T, E44D, S68G, R83K, V111I, V118I, I135V, S162A, M164L, K173T, Q174N, T200A, Q207E, R211K, P243A, V245Q, T286A, I293V, S322T, G335D, R356K, M357R, G359T, A360AV, A371V, I375V, A376T, K390R  
>7124-30902| codons 1-400
PISPIETVPVKLKPGVDGPKVKQWPLTEEKIKALTEICTELEKDGKISKIGPENPYNTPV
FAIKKKEGTKWRKLVDFRELNKKTQDFWEVQLGIPHPAGLKKKKSVTVLDIGDAYFSIPL
DKDFRKYTAFTIPSVNNETPGIRYQYNVLPQGWKGSPAIFQASLTKILEPFRTNNPDIVI
YQYVDDLYVGSDLEIGQHRAKIEELREHLWKWGFYTPDKKHQKEPPFLWMGYELHPDKWT
VQAIQLPEKDSWTVNDIQKLVGKLNWASQIYAGIKVKQLCKLLRGAKALTEVVPLTEEAE
LELAENREILKEPVHGVYYDPTKDLIAEIQKQGQDQWTYQIYQEPFKNLKTGKYAKRRTV
HTNDVKQLTEVVQKVTTESIVIWGKTPKFRLPIQKETWEA

References
Author Title Citation
Baxter, JD Genotypic changes in human immunodeficiency virus type 1 protease associated with reduced susceptibility and virologic response to the protease inhibitor tipranavir. J Virol, 2006