Isolate Data
| Patient | Isolate | Region | Year | Species | Subtype | Source | Clone Method |
| 48-7124 | 7124-30902 | Spain | 2003 | HIV1 | CRF02_AG | Plasma | None |
Treatment History
| Order | Regimen | Weeks |
| 1 | PI|NRTI|NNRTI | NA |
Protease Sequence
| PIMajorDRMs | PIMinorDRMs | Polys | UnusualMuts |
| M46I, I47V, L76V, I84V | Q58E | L10I, I13A, K14IR, L19P, K20I, M36I, N37D, R41K, K55KR, L63P, H69K, K70R, L89I |
| >7124-30902| codons 1-99 PQITLWQRPIVTARIGGQPIEALLDTGADDTVLEEIDLPGKWKPKIVGGIGGFIRVREYD QIPIEICGKRAIGTVVVGPTPVNVIGRNILTQIGCTLNF |
RT Sequence
| NRTIMajorDRMs | NRTIMinorDRMs | NNRTIMajorDRMs | NNRTIMinorDRMs | Polys | UnusualMuts |
| M41L, M184V, L210W, T215Y | D67DE | M16V, V35T, E44D, S68G, R83K, V111I, V118I, I135V, S162A, M164L, K173T, Q174N, T200A, Q207E, R211K, P243A, V245Q, T286A, I293V, S322T, G335D, R356K, M357R, G359T, A360AV, A371V, I375V, A376T, K390R |
| >7124-30902| codons 1-400 PISPIETVPVKLKPGVDGPKVKQWPLTEEKIKALTEICTELEKDGKISKIGPENPYNTPV FAIKKKEGTKWRKLVDFRELNKKTQDFWEVQLGIPHPAGLKKKKSVTVLDIGDAYFSIPL DKDFRKYTAFTIPSVNNETPGIRYQYNVLPQGWKGSPAIFQASLTKILEPFRTNNPDIVI YQYVDDLYVGSDLEIGQHRAKIEELREHLWKWGFYTPDKKHQKEPPFLWMGYELHPDKWT VQAIQLPEKDSWTVNDIQKLVGKLNWASQIYAGIKVKQLCKLLRGAKALTEVVPLTEEAE LELAENREILKEPVHGVYYDPTKDLIAEIQKQGQDQWTYQIYQEPFKNLKTGKYAKRRTV HTNDVKQLTEVVQKVTTESIVIWGKTPKFRLPIQKETWEA |
References
| Author | Title | Citation |
| Baxter, JD | Genotypic changes in human immunodeficiency virus type 1 protease associated with reduced susceptibility and virologic response to the protease inhibitor tipranavir. | J Virol, 2006 |