Isolate Data
| Patient | Isolate | Region | Year | Species | Subtype | Source | Clone Method |
| 48-7122 | 7122-30811 | Spain | 2003 | HIV1 | B | Plasma | None |
Treatment History
| Order | Regimen | Weeks |
| 1 | PI|NRTI|NNRTI | NA |
Protease Sequence
| PIMajorDRMs | PIMinorDRMs | Polys | UnusualMuts |
| M46I, I54IV, L76V, I84V | F53L | L10I, I13V, I15V, L19V, K20R, M36I, I62V, L63P, I64V |
| >7122-30811| codons 1-99 PQITLWQRPIVTVKVGGQVREALLDTGADDTVLEEINLPGRWKPKIIGGIGGLVKVRQYD QVPVEICGHKAIGTVVVGPTPVNVIGRNLLTQIGCTLNF |
RT Sequence
| NRTIMajorDRMs | NRTIMinorDRMs | NNRTIMajorDRMs | NNRTIMinorDRMs | Polys | UnusualMuts |
| M41L, L74V, L210W, T215Y | K103N | K43KE, K49R, V118I, D121Y, K122E, D123E, I135T, E169K, K173E, I178M, T200A, L228R, K263R, V292I, I293V, E297K, G359S, A371V |
| >7122-30811| codons 1-400 PISPIETVPVKLKPGMDGPKVKQWPLTEEKIKALVEICTELEEEGKISRIGPENPYNTPV FAIKKKDSTKWRKVVDFRELNKRTQDFWEVQLGIPHPAGLKKNKSVTVLDVGDAYFSIPL YEEFRKYTAFTIPSTNNETPGIRYQYNVLPQGWKGSPAIFQSSMTKILKPFREQNPDMVI YQYMDDLYVGSDLEIGQHRAKIEELRQHLWRWGFYTPDKKHQKEPPFRWMGYELHPDKWT VQPIVLPEKDSWTVNDIQKLVGRLNWASQIYAGIKVKQLCKLLRGTKALTEIVPLTKEAE LELAENREILKEPVHGVYYDPSKDLIAEIQKQGQGQWTYQIYQEPFKNLKTGKYARMRSA HTNDVKQLTEVVQKIATESIVIWGKTPKFKLPIQKETWEA |
References
| Author | Title | Citation |
| Baxter, JD | Genotypic changes in human immunodeficiency virus type 1 protease associated with reduced susceptibility and virologic response to the protease inhibitor tipranavir. | J Virol, 2006 |