Isolate Data
| Patient | Isolate | Region | Year | Species | Subtype | Source | Clone Method |
| 48-7121 | 7121-30610 | Spain | 2003 | HIV1 | B | Plasma | None |
Treatment History
| Order | Regimen | Weeks |
| 1 | PI|NRTI|NNRTI | NA |
Protease Sequence
| PIMajorDRMs | PIMinorDRMs | Polys | UnusualMuts |
| M46I, I54V, V82F, L90M | L33LF, G73C | L10I, E35D, N37D, I62V, L63P, A71T, I72E, I93L |
| >7121-30610| codons 1-99 PQITLWQRPIVTIKIGGQLKEALLDTGADDTVFEDMDLPGRWKPKIIGGIGGFVKVRQYD QVPIEICGHKTECTVLVGPTPFNIIGRNLMTQLGCTLNF |
RT Sequence
| NRTIMajorDRMs | NRTIMinorDRMs | NNRTIMajorDRMs | NNRTIMinorDRMs | Polys | UnusualMuts |
| M41L, D67N, T69D, L210W, T215Y | K103KN, G190GA | K43N, D123E, I178L, V179VI, T200A, E203K, Q207D, H208Y, R211K, A272P, K277R, T286A, I329IV, G333E, Q334H, A371V, T377V, S379C, K390R |
| >7121-30610| codons 1-399 PISPIETVPVKLKPGMDGPKVKQWPLTEEKIKALVEICTELENEGKISKIGPENPYNTPV FAIKKKNSDKWRKLVDFRELNKRTQDFWEVQLGIPHPAGLKKNKSVTVLDVGDAYFSVPL DKEFRKYTAFTIPSINNETPGIRYQYNVLPQGWKGSPAIFQSSMTKILEPFRKQNPDLII YQYMDDLYVASDLEIGQHRAKIKELRDYLWKWGFYTPDKKHQKEPPFLWMGYELHPDKWT VQPIVLPEKDSWTVNDIQKLVGKLNWASQIYPGIKVRQLCKLLRGAKALTEVIPLTEEAE LELAENREILKEPVHGVYYDPSKDLIAEVQKQEHGQWTYQIYQEPFKNLKTGKYARMRGA HTNDVKQLTEVVQKIAVECIVIWGKTPKFRLPIQKETWE |
References
| Author | Title | Citation |
| Baxter, JD | Genotypic changes in human immunodeficiency virus type 1 protease associated with reduced susceptibility and virologic response to the protease inhibitor tipranavir. | J Virol, 2006 |