Isolate Data
| Patient | Isolate | Region | Year | Species | Subtype | Source | Clone Method |
| 48-7110 | 7110-30930 | Spain | 2003 | HIV1 | B | Plasma | None |
Treatment History
| Order | Regimen | Weeks |
| 1 | PI|NRTI|NNRTI | NA |
Protease Sequence
| PIMajorDRMs | PIMinorDRMs | Polys | UnusualMuts |
| M46I, I47V, I54M, V82A, L90M | F53FL | L10V, L19I, K20R, E34Q, N37T, R41K, L63P, A71V, V77I, I93L |
| >7110-30930| codons 1-99 PQITLWQRPVVTIKIGGQIREALLDTGADDTVLQEMTLPGKWKPKIVGGIGGLMKVRQYD QIPIEICGHKVIGTVLIGPTPANIIGRNLMTQLGCTLNF |
RT Sequence
| NRTIMajorDRMs | NRTIMinorDRMs | NNRTIMajorDRMs | NNRTIMinorDRMs | Polys | UnusualMuts |
| D67N, T69D, K70KR, L74I, V75T, M184V, T215F | K219Q | K101P, K103S | K20R, E28K, V35I, V118I, K122E, I135T, E169D, D177E, I178M, G196E, H208HY, F214L, A272P, P294A, Q334L, M357T, G359S, A371V, A376T, T386A |
| >7110-30930| codons 1-399 PISPIETVPVKLKPGMDGPRVKQWPLTKEKIKALIEICTEMEKEGKISKIGPENPYNTPV FAIKKKNSDRWRKITDFRELNKRTQDFWEVQLGIPHPAGLPKSKSVTVLDVGDAYFSIPL DEDFRKYTAFTIPSTNNETPGIRYQYNVLPQGWKGSPAIFQSSMTKILDPFRKQNPEMVI YQYVDDLYVGSDLEIEQHRTKIEELRQYLLRWGLFTPDQKHQKEPPFLWMGYELHPDKWT VQPIVLPEKDSWTVNDIQKLVGKLNWASQIYPGIKVKQLCKLLRGTKALTEVIALTEEAE LELAENREILKEPVHGVYYDPSKDLIAEIQKQGLGQWTYQIYQEPFKNLKTGKYARTRSA HTNDVKQLTEVVQKITTESIVIWGKAPKFKLPIQKETWE |
References
| Author | Title | Citation |
| Baxter, JD | Genotypic changes in human immunodeficiency virus type 1 protease associated with reduced susceptibility and virologic response to the protease inhibitor tipranavir. | J Virol, 2006 |