Isolate Data
| Patient | Isolate | Region | Year | Species | Subtype | Source | Clone Method |
| 48-7109 | 7109-30922 | Spain | 2003 | HIV1 | B | Plasma | None |
Treatment History
| Order | Regimen | Weeks |
| 1 | PI|NRTI|NNRTI | NA |
RT Sequence
| NRTIMajorDRMs | NRTIMinorDRMs | NNRTIMajorDRMs | NNRTIMinorDRMs | Polys | UnusualMuts |
| M41L, D67N, L74V, V75T, Y115F, M184V, T215F | K219Q | L100I, K103N | T69N, A98S, V118I, K122E, V179VI, I202V, Q207E, R211RK, D218E, A272P, I293IV, Q334L, R356K, T369A, A376S, T377L |
| >7109-30922| codons 1-399 PISPIETVPVKLKPGMDGPKVKQWPLTEEKIKALVEICTELEKEGKISKIGPENPYNTPV FAIKKKNSNKWRKVTDFRELNKRTQDFWEVQLGIPHPSGIKKNKSVTVLDVGDAFFSIPL DEDFRKYTAFTIPSINNETPGIRYQYNVLPQGWKGSPAIFQSSMTKILEPFRKQNPDIII YQYVDDLYVGSDLEIGQHRTKVEELREHLLKWGFFTPEQKHQKEPPFLWMGYELHPDKWT VQPIVLPEKDSWTVNDIQKLVGKLNWASQIYPGIKVKQLCKLLRGTKALTEVVPLTEEAE LELAENREILKEPVHGVYYDPSKDLIAEIQKQGLGQWTYQIYQEPFKNLKTGKYAKMRGA HTNDVKQLAEAVQKISLESIVIWGKTPKFKLPIQKETWE |
Protease Sequence
| PIMajorDRMs | PIMinorDRMs | Polys | UnusualMuts |
| V32I, M46MIL, I47A, L90M | L33F | L10I, E34Q, R41K, I62V, L63P, C67X, A71T, I72T, V77I, I93L |
| >7109-30922| codons 1-99 PQITLWQRPIVTIKIGGQLKEALLDTGADDTIFQEMNLPGKWKPKLAGGIGGFIKVRQYD QVPIEIXGHKTTGTVLIGPTPVNIIGRNLMTQLGCTLNF |
References
| Author | Title | Citation |
| Baxter, JD | Genotypic changes in human immunodeficiency virus type 1 protease associated with reduced susceptibility and virologic response to the protease inhibitor tipranavir. | J Virol, 2006 |