Isolate Data
| Patient | Isolate | Region | Year | Species | Subtype | Source | Clone Method |
| 48-7107 | 7107-30929 | Spain | 2003 | HIV1 | B | Plasma | None |
Treatment History
| Order | Regimen | Weeks |
| 1 | PI|NRTI|NNRTI | NA |
RT Sequence
| NRTIMajorDRMs | NRTIMinorDRMs | NNRTIMajorDRMs | NNRTIMinorDRMs | Polys | UnusualMuts |
| M41L, D67N, T69D, L74V, L210W, T215Y | K219R | Y181C | A98G, V108I | T39AE, E44D, V118I, K122E, I135T, G196E, I202V, E203D, H208F, R211K, H221Y, I293V, P294Q, K311R, Q334E, G335S, R356K, M357T, K366R, T386I, K390R |
| >7107-30929| codons 1-399 PISPIETVPVKLKPGMDGPKVKQWPLTEEKIKALVEICEELEKDGKISKIGPENPYNTPV FAIKKKNSDKWRKVVDFRELNKRTQDFWEVQLGIPHPGGLKKKKSVTILDVGDAYFSIPL DEDFRKYTAFTIPSTNNETPGIRYQYNVLPQGWKGSPAIFQSSMTKILEPFRKQNPDIVI CQYMDDLYVGSDLEIEQHRTKVDELRQFLWKWGFYTPDRKYQKEPPFLWMGYELHPDKWT VQPIVLPEKDSWTVNDIQKLVGKLNWASQIYAGIKVKQLCKLLRGTKALTEVVQLTEEAE LELAENREILREPVHGVYYDPSKDLIAEIQKQGESQWTYQIYQEPFKNLKTGKYAKTRGA HTNDVRQLTEAVQKIATESIVIWGKIPKFRLPIQKETWE |
Protease Sequence
| PIMajorDRMs | PIMinorDRMs | Polys | UnusualMuts |
| V32I, M46I, I47IV, L90M | L10F | K20I, L38I, I62V, L63P, I64V, G73V, V77I |
| >7107-30929| codons 1-99 PQITLWQRPFVTIKIGGQLIEALLDTGADDTILEEMNIPGRWKPKIVGGIGGFIKVRQYD QVPVEICGHKAIVTVLIGPTPVNIIGRNLMTQIGCTLNF |
References
| Author | Title | Citation |
| Baxter, JD | Genotypic changes in human immunodeficiency virus type 1 protease associated with reduced susceptibility and virologic response to the protease inhibitor tipranavir. | J Virol, 2006 |