Isolate Data
| Patient | Isolate | Region | Year | Species | Subtype | Source | Clone Method |
| 48-7106 | 7106-30910 | Spain | 2003 | HIV1 | B | Plasma | None |
Treatment History
| Order | Regimen | Weeks |
| 1 | PI|NRTI|NNRTI | NA |
RT Sequence
| NRTIMajorDRMs | NRTIMinorDRMs | NNRTIMajorDRMs | NNRTIMinorDRMs | Polys | UnusualMuts |
| M41L, V75M, M184V, L210W, T215Y | N348I | K103N | V35I, K43E, E44D, R83K, V90I, K102R, V118I, K122E, S162N, I178M, G196E, R211K, L228R, V245M, A272P, L283I, I293V, P294T, A355G, R356K, G359S, K366R, A371V, K385R, K390R |
| >7106-30910| codons 1-400 PISPIETVPVKLKPGMDGPKVKQWPLTEEKIKALIEICTELEEDGKISKIGPENPYNTPV FAIKKKDSTKWRKLMDFRELNKKTQDFWEIQLGIPHPAGLKRNKSVTVLDVGDAYFSIPL DEDFRKYTAFTIPSINNETPGIRYQYNVLPQGWKGSPAIFQNSMTKILEPFRKQNPDMVI YQYVDDLYVGSDLEIEQHRTKIEELRQHLWKWGFYTPDKKHQKEPPFRWMGYELHPDKWT VQPIMLPEKDSWTVNDIQKLVGKLNWASQIYPGIKVKQLCKLIRGTKALTEVVTLTEEAE LELAENREILKEPVHGVYYDPSKDLIAEIQKQGQGQWTYQIYQEPFKILKTGKYGKMRSA HTNDVRQLTEVVQKIATESIVIWGRTPKFRLPIQKETWEA |
Protease Sequence
| PIMajorDRMs | PIMinorDRMs | Polys | UnusualMuts |
| V32I, M46I, I54V, I84V, L90M | L10F, V11I, G73S, L89LV | I15V, K20I, M36I, R41K, K55R, L63P, E65D, A71V |
| >7106-30910| codons 1-99 PQITLWQRPFITIKVGGQLIEALLDTGADDTILEEINLPGKWKPKIIGGIGGFVRVRQYD QIPIDICGHKVISTVLVGPTPVNVIGRNVMTQIGCTLNF |
References
| Author | Title | Citation |
| Baxter, JD | Genotypic changes in human immunodeficiency virus type 1 protease associated with reduced susceptibility and virologic response to the protease inhibitor tipranavir. | J Virol, 2006 |