Isolate Data
| Patient | Isolate | Region | Year | Species | Subtype | Source | Clone Method |
| 48-7104 | 7104-30818 | Spain | 2003 | HIV1 | B | Plasma | None |
Treatment History
| Order | Regimen | Weeks |
| 1 | PI|NRTI|NNRTI | NA |
Protease Sequence
| PIMajorDRMs | PIMinorDRMs | Polys | UnusualMuts |
| V32I, I47A, V82A | I15IV, K20R, M36I, N37D, I62V, L63P, A71AV, I72V, I93L |
| >7104-30818| codons 1-99 PQITLWQRPLVTIKVGGQLREALLDTGADDTILEEIDLPGRWKPKMAGGIGGFIKVRQYD QVPIEICGHKVVGTVLVGPTPANIIGRNLLTQLGCTLNF |
RT Sequence
| NRTIMajorDRMs | NRTIMinorDRMs | NNRTIMajorDRMs | NNRTIMinorDRMs | Polys | UnusualMuts |
| D67N, K70R, M184MV, T215F | K219E | K103N, G190GA | V108I | P4PT, V60I, V118I, D123E, I135IM, Q174H, D192DN, G196GE, Q207E, R211K, F214L, L228LR, A272P, E297K, Q334I, M357T, A371V |
| >7104-30818| codons 1-399 PISTIETVPVKLKPGMDGPKVKQWPLTEEKIKALVEICTEMEKEGKISKIGPENPYNTPI FAIKKKNSTRWRKLVDFRELNKRTQDFWEVQLGIPHPAGLKKNKSVTILDVGDAYFSIPL DKEFRKYTAFTIPSMNNETPGIRYQYNVLPQGWKGSPAIFQSSMTKILEPFRKHNPDIVI YQYVDDLYVASNLEIEQHRTKIEELREHLLKWGLFTPDEKHQKEPPFRWMGYELHPDKWT VQPIVLPEKDSWTVNDIQKLVGKLNWASQIYPGIKVKQLCKLLRGTKALTEVIPLTKEAE LELAENREILKEPVHGVYYDPSKDLIAEIQKQGIGQWTYQIYQEPFKNLKTGKYARTRGA HTNDVKQLTEVVQKIATESIVIWGKTPKFKLPIQKETWE |
References
| Author | Title | Citation |
| Baxter, JD | Genotypic changes in human immunodeficiency virus type 1 protease associated with reduced susceptibility and virologic response to the protease inhibitor tipranavir. | J Virol, 2006 |