Isolate Data
| Patient | Isolate | Region | Year | Species | Subtype | Source | Clone Method |
| 48-7103 | 7103-30811 | Spain | 2003 | HIV1 | B | Plasma | None |
Treatment History
| Order | Regimen | Weeks |
| 1 | PI|NRTI|NNRTI | NA |
RT Sequence
| NRTIMajorDRMs | NRTIMinorDRMs | NNRTIMajorDRMs | NNRTIMinorDRMs | Polys | UnusualMuts |
| M41L, D67N, T69D, L74V, L210W, T215Y | Y188L | A98G, V179E | T39A, E44ED, V60I, V106I, V118I, K122KE, I142V, E169D, T200A, Q207E, H208Y, R211K, E224D, V245R, K277R, T286A, E297R, E312AT, I329L, G333E, Q334P, F346Y, K350R, R356K, G359S, T386I, Q394H |
| >7103-30811| codons 1-400 PISPIETVPVKLKPGMDGPKVKQWPLTEEKIKALVEICAELEKDGKISKIGPENPYNTPI FAIKKKNSDKWRKVVDFRELNKRTQDFWEVQLGIPHPGGLKKKKSITVLDVGDAYFSIPL DEDFRKYTAFTIPSINNETPGVRYQYNVLPQGWKGSPAIFQSSMTKILDPFRKQNPDIEI YQYMDDLLVGSDLEIGQHRAKIEELREYLWKWGFYTPDKKHQKDPPFLWMGYELHPDKWT VQPIRLPEKDSWTVNDIQKLVGKLNWASQIYAGIKVRQLCKLLRGAKALTEVIPLTREAE LELAENREILKTPVHGVYYDPSKDLIAELQKQEPGQWTYQIYQEPYKNLRTGKYAKMRSA HTNDVKQLTEAVQKIATESIVIWGKIPKFKLPIHKETWEA |
Protease Sequence
| PIMajorDRMs | PIMinorDRMs | Polys | UnusualMuts |
| M46I, I54L, L76V, I84V, L90M | L33F | L10I, I13V, R57K, I62V, L63P, I66V, A71V, I93L |
| >7103-30811| codons 1-99 PQITLWQRPIVTVKIGGQLKEALLDTGADDTVFEEMNLPGRWKPKIIGGIGGFLKVKQYD QVPIEVCGHKVIGTVVVGPTPVNVIGRNLMTQLGCTLNF |
References
| Author | Title | Citation |
| Baxter, JD | Genotypic changes in human immunodeficiency virus type 1 protease associated with reduced susceptibility and virologic response to the protease inhibitor tipranavir. | J Virol, 2006 |