<!--#if expr="$title" --> <!--#echo var="title" --> <!--#else --> HIV Drug Resistance Database <!--#endif -->
Stanford University HIV Drug Resistance Database - A curated public database designed to represent, store, and analyze the divergent forms of data underlying HIV drug resistance.

Isolate Data

Patient Isolate Region Year Species Subtype Source Clone Method
48-7103 7103-30811 Spain 2003 HIV1 B Plasma None

Treatment History
Order Regimen Weeks
1 PI|NRTI|NNRTI NA

Protease Sequence
PIMajorDRMs PIMinorDRMs Polys UnusualMuts
M46I, I54L, L76V, I84V, L90M L33F L10I, I13V, R57K, I62V, L63P, I66V, A71V, I93L  
>7103-30811| codons 1-99
PQITLWQRPIVTVKIGGQLKEALLDTGADDTVFEEMNLPGRWKPKIIGGIGGFLKVKQYD
QVPIEVCGHKVIGTVVVGPTPVNVIGRNLMTQLGCTLNF

RT Sequence
NRTIMajorDRMs NRTIMinorDRMs NNRTIMajorDRMs NNRTIMinorDRMs Polys UnusualMuts
M41L, D67N, T69D, L74V, L210W, T215Y   Y188L A98G, V179E T39A, E44ED, V60I, V106I, V118I, K122KE, I142V, E169D, T200A, Q207E, H208Y, R211K, E224D, V245R, K277R, T286A, E297R, E312AT, I329L, G333E, Q334P, F346Y, K350R, R356K, G359S, T386I, Q394H  
>7103-30811| codons 1-400
PISPIETVPVKLKPGMDGPKVKQWPLTEEKIKALVEICAELEKDGKISKIGPENPYNTPI
FAIKKKNSDKWRKVVDFRELNKRTQDFWEVQLGIPHPGGLKKKKSITVLDVGDAYFSIPL
DEDFRKYTAFTIPSINNETPGVRYQYNVLPQGWKGSPAIFQSSMTKILDPFRKQNPDIEI
YQYMDDLLVGSDLEIGQHRAKIEELREYLWKWGFYTPDKKHQKDPPFLWMGYELHPDKWT
VQPIRLPEKDSWTVNDIQKLVGKLNWASQIYAGIKVRQLCKLLRGAKALTEVIPLTREAE
LELAENREILKTPVHGVYYDPSKDLIAELQKQEPGQWTYQIYQEPYKNLRTGKYAKMRSA
HTNDVKQLTEAVQKIATESIVIWGKIPKFKLPIHKETWEA

References
Author Title Citation
Baxter, JD Genotypic changes in human immunodeficiency virus type 1 protease associated with reduced susceptibility and virologic response to the protease inhibitor tipranavir. J Virol, 2006