Isolate Data
| Patient | Isolate | Region | Year | Species | Subtype | Source | Clone Method |
| 48-7102 | 7102-40225 | Spain | 2004 | HIV1 | B | Plasma | None |
Treatment History
| Order | Regimen | Weeks |
| 1 | PI|NRTI|NNRTI | NA |
| 2 | NRTI+NNRTI+RTV+TPV | 30 |
Protease Sequence
| PIMajorDRMs | PIMinorDRMs | Polys | UnusualMuts |
| M46I, I47A, I84V | L10V, I13V, K20T, L33V, M36I, N37C, R57K, L63P, I64V |
| >7102-40225| codons 1-99 PQITLWQRPVVTVKIGGQLTEALLDTGADDTVVEEICLPGRWKPKIAGGIGGFIKVKQYD QIPVEICGHKAIGTVLVGPTPVNVIGRNLLTQIGCTLNF |
RT Sequence
| NRTIMajorDRMs | NRTIMinorDRMs | NNRTIMajorDRMs | NNRTIMinorDRMs | Polys | UnusualMuts |
| K65R, K70R, Q151M | V75I, F77L, F116Y | K103N | P4T, T27TS, K32R, K49R, I50V, S68G, R83K, K122E, S163T, T165I, E169D, I195L, T200A, E203EQ, Q207E, R211K, F214L, A272P, R284RK, I293V, D324E, T369A, A376T, T386TA | L228C |
| >7102-40225| codons 1-399 PISTIETVPVKLKPGMDGPKVKQWPLSEEKIRALVEICTEMEKEGKISRVGPENPYNTPV FAIKRKDGTRWRKLIDLRELNKKTQDFWEVQLGIPHPAGLKKNKSVTVLDVGDAYYSVPL DEDFRKYTAFTIPSINNETPGIRYQYNVLPMGWKGSPAIFQSTMIKILDPFRKQNPDIVI YQYMDDLYVGSDLELGQHRAKIQELREHLLKWGLTTPDKKHQKEPPFCWMGYELHPDKWT VQPIVLPEKDSWTVNDIQKLVGKLNWASQIYPGIKVKQLCKLLKGTKALTEVVPLTEEAE LELAENREILKEPVHGVYYDPSKELIAEIQKQGQGQWTYQIYQEPFKNLKTGKYARMRGA HTNDVKQLAEAVQKITTESIVIWGKAPKFKLPIQKETWE |
References
| Author | Title | Citation |
| Baxter, JD | Genotypic changes in human immunodeficiency virus type 1 protease associated with reduced susceptibility and virologic response to the protease inhibitor tipranavir. | J Virol, 2006 |