<!--#if expr="$title" --> <!--#echo var="title" --> <!--#else --> HIV Drug Resistance Database <!--#endif -->
Stanford University HIV Drug Resistance Database - A curated public database designed to represent, store, and analyze the divergent forms of data underlying HIV drug resistance.

Isolate Data

Patient Isolate Region Year Species Subtype Source Clone Method
48-7102 7102-40225 Spain 2004 HIV1 B Plasma None

Treatment History
Order Regimen Weeks
1 PI|NRTI|NNRTI NA
2 NRTI+NNRTI+RTV+TPV 30

Protease Sequence
PIMajorDRMs PIMinorDRMs Polys UnusualMuts
M46I, I47A, I84V   L10V, I13V, K20T, L33V, M36I, N37C, R57K, L63P, I64V  
>7102-40225| codons 1-99
PQITLWQRPVVTVKIGGQLTEALLDTGADDTVVEEICLPGRWKPKIAGGIGGFIKVKQYD
QIPVEICGHKAIGTVLVGPTPVNVIGRNLLTQIGCTLNF

RT Sequence
NRTIMajorDRMs NRTIMinorDRMs NNRTIMajorDRMs NNRTIMinorDRMs Polys UnusualMuts
K65R, K70R, Q151M V75I, F77L, F116Y K103N   P4T, T27TS, K32R, K49R, I50V, S68G, R83K, K122E, S163T, T165I, E169D, I195L, T200A, E203EQ, Q207E, R211K, F214L, A272P, R284RK, I293V, D324E, T369A, A376T, T386TA L228C
>7102-40225| codons 1-399
PISTIETVPVKLKPGMDGPKVKQWPLSEEKIRALVEICTEMEKEGKISRVGPENPYNTPV
FAIKRKDGTRWRKLIDLRELNKKTQDFWEVQLGIPHPAGLKKNKSVTVLDVGDAYYSVPL
DEDFRKYTAFTIPSINNETPGIRYQYNVLPMGWKGSPAIFQSTMIKILDPFRKQNPDIVI
YQYMDDLYVGSDLELGQHRAKIQELREHLLKWGLTTPDKKHQKEPPFCWMGYELHPDKWT
VQPIVLPEKDSWTVNDIQKLVGKLNWASQIYPGIKVKQLCKLLKGTKALTEVVPLTEEAE
LELAENREILKEPVHGVYYDPSKELIAEIQKQGQGQWTYQIYQEPFKNLKTGKYARMRGA
HTNDVKQLAEAVQKITTESIVIWGKAPKFKLPIQKETWE

References
Author Title Citation
Baxter, JD Genotypic changes in human immunodeficiency virus type 1 protease associated with reduced susceptibility and virologic response to the protease inhibitor tipranavir. J Virol, 2006