<!--#if expr="$title" --> <!--#echo var="title" --> <!--#else --> HIV Drug Resistance Database <!--#endif -->
Stanford University HIV Drug Resistance Database - A curated public database designed to represent, store, and analyze the divergent forms of data underlying HIV drug resistance.

Isolate Data

Patient Isolate Region Year Species Subtype Source Clone Method
48-7101 7101-30723 Spain 2003 HIV1 C Plasma None

Treatment History
Order Regimen Weeks
1 PI|NRTI|NNRTI NA

RT Sequence
NRTIMajorDRMs NRTIMinorDRMs NNRTIMajorDRMs NNRTIMinorDRMs Polys UnusualMuts
M41L, D67N, K70R, L210W, T215Y K219Q, N348I K103N   V35I, T39E, E44ED, V60I, V118I, K122E, D123G, I135T, K173T, Q174K, T200A, E203ED, Q207E, R211K, V245Q, D250DE, A272P, K277R, T286A, E291D, V292I, I293V, G335D, R356K, M357R, G359A, T377M, A400S  
>7101-30723| codons 1-400
PISPIETVPVKLKPGMDGPKVKQWPLTEEKIKALIEICEELEKDGKISKIGPENPYNTPI
FAIKKKNSTRWRKLVDFRELNKRTQDFWEVQLGIPHPAGLKKNKSVTVLDVGDAYFSIPL
DEGFRKYTAFTIPSTNNETPGIRYQYNVLPQGWKGSPAIFQSSMTKILEPFRTKNPDIVI
YQYMDDLYVGSDLEIGQHRAKIDELREHLWKWGFYTPDQKHQKEPPFLWMGYELHPDKWT
VQPIQLPEKESWTVNDIQKLVGKLNWASQIYPGIKVRQLCKLLRGAKALTDIVPLTEEAE
LELAENREILKEPVHGVYYDPSKDLIAEIQKQGQDQWTYQIYQEPFKILKTGKYAKRRAA
HTNDVKQLTEAVQKIAMESIVIWGKTPKFKLPIQKETWES

Protease Sequence
PIMajorDRMs PIMinorDRMs Polys UnusualMuts
M46I, I54V, V82A L10F, L24I T12P, I13V, L19I, K20I, E35D, M36I, R41K, L63P, H69K, T74AS, L89M, I93L  
>7101-30723| codons 1-99
PQITLWQRPFVPVKIGGQIIEALIDTGADDTVLEDINLPGKWKPKIIGGIGGFVKVRQYD
QIPIEICGKKAIGSVLVGPTPANIIGRNMLTQLGCTLNF

References
Author Title Citation
Baxter, JD Genotypic changes in human immunodeficiency virus type 1 protease associated with reduced susceptibility and virologic response to the protease inhibitor tipranavir. J Virol, 2006