<!--#if expr="$title" --> <!--#echo var="title" --> <!--#else --> HIV Drug Resistance Database <!--#endif -->
Stanford University HIV Drug Resistance Database - A curated public database designed to represent, store, and analyze the divergent forms of data underlying HIV drug resistance.

Isolate Data

Patient Isolate Region Year Species Subtype Source Clone Method
48-7100 7100-30721 Spain 2003 HIV1 B Plasma None

Treatment History
Order Regimen Weeks
1 PI|NRTI|NNRTI NA

Protease Sequence
PIMajorDRMs PIMinorDRMs Polys UnusualMuts
M46MI, I50V, I54V, V82A, L90M L10F, L33I, G73S, L89V I13V, L19I, K20M, E35D, M36I, R41K, I62V, L63P, A71V, I72IM  
>7100-30721| codons 1-99
PQITLWQRPFVTVKIGGQIMEALLDTGADDTVIEDINLPGKWKPKIIGGVGGFVKVRQYD
QVPIEICGHKVMSTVLVGPTPANIIGRNVMTQIGCTLNF

RT Sequence
NRTIMajorDRMs NRTIMinorDRMs NNRTIMajorDRMs NNRTIMinorDRMs Polys UnusualMuts
M41L, D67N, L210W, T215Y K219N     V35VI, T39TA, E44D, V118I, K122E, D123E, S162C, D177DE, I178IM, G196E, Q197H, I202V, Q207N, R211K, A272P, L283I, E297EK, D324E, A355G, R356K, R358K, G359S, A360T, A376S, T386I, K390R, K395KR  
>7100-30721| codons 1-399
PISPIETVPVKLKPGMDGPKVKQWPLTEEKIKALIEICAELEKDGKISKIGPENPYNTPV
FAIKKKNSTKWRKLVDFRELNKRTQDFWEVQLGIPHPAGLKKKKSVTVLDVGDAYFSIPL
DEEFRKYTAFTIPSINNETPGIRYQYNVLPQGWKGSPAIFQCSMTKILEPFRKQNPEMVI
YQYMDDLYVGSDLEIEHHRTKVEELRNHLWKWGFYTPDNKHQKEPPFLWMGYELHPDKWT
VQPIVLPEKDSWTVNDIQKLVGKLNWASQIYPGIKVKQLCKLIRGTKALTEVIPLTKEAE
LELAENREILKEPVHGVYYDPSKELIAEIQKQGQGQWTYQIYQEPFKNLKTGKYGKMKST
HTNDVKQLTEAVQKISTESIVIWGKIPKFRLPIQRETWE

References
Author Title Citation
Baxter, JD Genotypic changes in human immunodeficiency virus type 1 protease associated with reduced susceptibility and virologic response to the protease inhibitor tipranavir. J Virol, 2006