Isolate Data
| Patient | Isolate | Region | Year | Species | Subtype | Source | Clone Method |
| 48-7100 | 7100-30721 | Spain | 2003 | HIV1 | B | Plasma | None |
Treatment History
| Order | Regimen | Weeks |
| 1 | PI|NRTI|NNRTI | NA |
Protease Sequence
| PIMajorDRMs | PIMinorDRMs | Polys | UnusualMuts |
| M46MI, I50V, I54V, V82A, L90M | L10F, L33I, G73S, L89V | I13V, L19I, K20M, E35D, M36I, R41K, I62V, L63P, A71V, I72IM |
| >7100-30721| codons 1-99 PQITLWQRPFVTVKIGGQIMEALLDTGADDTVIEDINLPGKWKPKIIGGVGGFVKVRQYD QVPIEICGHKVMSTVLVGPTPANIIGRNVMTQIGCTLNF |
RT Sequence
| NRTIMajorDRMs | NRTIMinorDRMs | NNRTIMajorDRMs | NNRTIMinorDRMs | Polys | UnusualMuts |
| M41L, D67N, L210W, T215Y | K219N | V35VI, T39TA, E44D, V118I, K122E, D123E, S162C, D177DE, I178IM, G196E, Q197H, I202V, Q207N, R211K, A272P, L283I, E297EK, D324E, A355G, R356K, R358K, G359S, A360T, A376S, T386I, K390R, K395KR |
| >7100-30721| codons 1-399 PISPIETVPVKLKPGMDGPKVKQWPLTEEKIKALIEICAELEKDGKISKIGPENPYNTPV FAIKKKNSTKWRKLVDFRELNKRTQDFWEVQLGIPHPAGLKKKKSVTVLDVGDAYFSIPL DEEFRKYTAFTIPSINNETPGIRYQYNVLPQGWKGSPAIFQCSMTKILEPFRKQNPEMVI YQYMDDLYVGSDLEIEHHRTKVEELRNHLWKWGFYTPDNKHQKEPPFLWMGYELHPDKWT VQPIVLPEKDSWTVNDIQKLVGKLNWASQIYPGIKVKQLCKLIRGTKALTEVIPLTKEAE LELAENREILKEPVHGVYYDPSKELIAEIQKQGQGQWTYQIYQEPFKNLKTGKYGKMKST HTNDVKQLTEAVQKISTESIVIWGKIPKFRLPIQRETWE |
References
| Author | Title | Citation |
| Baxter, JD | Genotypic changes in human immunodeficiency virus type 1 protease associated with reduced susceptibility and virologic response to the protease inhibitor tipranavir. | J Virol, 2006 |