<!--#if expr="$title" --> <!--#echo var="title" --> <!--#else --> HIV Drug Resistance Database <!--#endif -->
Stanford University HIV Drug Resistance Database - A curated public database designed to represent, store, and analyze the divergent forms of data underlying HIV drug resistance.

Isolate Data

Patient Isolate Region Year Species Subtype Source Clone Method
48-7099 7099-30714 Spain 2003 HIV1 B Plasma None

Treatment History
Order Regimen Weeks
1 PI|NRTI|NNRTI NA

RT Sequence
NRTIMajorDRMs NRTIMinorDRMs NNRTIMajorDRMs NNRTIMinorDRMs Polys UnusualMuts
K65R, K70R, Y115F, Q151M, M184V V75I, F77L, F116Y, K219E Y181C, G190A K101H S68G, V118I, K122E, I135T, T165I, R172K, T200TA, F214L, A272P, T286A, K311R, D324DE, I326V, Q334QK, A360T, T369V, A376AS, K388R, K390R  
>7099-30714| codons 1-399
PISPIETVPVKLKPGMDGPKVKQWPLTEEKIKALVEICTEMEKEGKISKIGPENPYNTPV
FAIKRKDGTRWRKLIDLRELNKRTQDFWEVQLGIPHPAGLHKKKSVTVLDVGDAFYSIPL
DEDFRKYTAFTIPSTNNETPGIRYQYNVLPMGWKGSPAIFQSSMIKILEPFKKQNPDIVI
CQYVDDLYVASDLEIGQHRAKIEELRQHLLRWGLTTPDEKHQKEPPFLWMGYELHPDKWT
VQPIVLPEKDSWTVNDIQKLVGKLNWASQIYPGIKVKQLCKLLRGAKALTEVIPLTEEAE
LELAENREILREPVHGVYYDPSKELVAEIQKQGKGQWTYQIYQEPFKNLKTGKYARMRGT
HTNDVKQLVEAVQKISTESIVIWGKTPRFRLPIQKETWE

Protease Sequence
PIMajorDRMs PIMinorDRMs Polys UnusualMuts
M46L, I50V, I54V, V82F, L90M L10F, V11I, L33F, G73S, I84L, L89V T4P, I13V, K14R, E35D, M36L, N37S, I62V, L63P, H69Q, K70T, A71V, I93L  
>7099-30714| codons 1-99
PQIPLWQRPFITVRIGGQLKEALLDTGADDTVFEDLSLPGRWKPKLIGGVGGFVKVRQYD
QVPIEICGQTVISTVLVGPTPFNLIGRNVMTQLGCTLNF

References
Author Title Citation
Baxter, JD Genotypic changes in human immunodeficiency virus type 1 protease associated with reduced susceptibility and virologic response to the protease inhibitor tipranavir. J Virol, 2006