Isolate Data
| Patient | Isolate | Region | Year | Species | Subtype | Source | Clone Method |
| 48-7099 | 7099-30714 | Spain | 2003 | HIV1 | B | Plasma | None |
Treatment History
| Order | Regimen | Weeks |
| 1 | PI|NRTI|NNRTI | NA |
Protease Sequence
| PIMajorDRMs | PIMinorDRMs | Polys | UnusualMuts |
| M46L, I50V, I54V, V82F, L90M | L10F, V11I, L33F, G73S, I84L, L89V | T4P, I13V, K14R, E35D, M36L, N37S, I62V, L63P, H69Q, K70T, A71V, I93L |
| >7099-30714| codons 1-99 PQIPLWQRPFITVRIGGQLKEALLDTGADDTVFEDLSLPGRWKPKLIGGVGGFVKVRQYD QVPIEICGQTVISTVLVGPTPFNLIGRNVMTQLGCTLNF |
RT Sequence
| NRTIMajorDRMs | NRTIMinorDRMs | NNRTIMajorDRMs | NNRTIMinorDRMs | Polys | UnusualMuts |
| K65R, K70R, Y115F, Q151M, M184V | V75I, F77L, F116Y, K219E | Y181C, G190A | K101H | S68G, V118I, K122E, I135T, T165I, R172K, T200TA, F214L, A272P, T286A, K311R, D324DE, I326V, Q334QK, A360T, T369V, A376AS, K388R, K390R |
| >7099-30714| codons 1-399 PISPIETVPVKLKPGMDGPKVKQWPLTEEKIKALVEICTEMEKEGKISKIGPENPYNTPV FAIKRKDGTRWRKLIDLRELNKRTQDFWEVQLGIPHPAGLHKKKSVTVLDVGDAFYSIPL DEDFRKYTAFTIPSTNNETPGIRYQYNVLPMGWKGSPAIFQSSMIKILEPFKKQNPDIVI CQYVDDLYVASDLEIGQHRAKIEELRQHLLRWGLTTPDEKHQKEPPFLWMGYELHPDKWT VQPIVLPEKDSWTVNDIQKLVGKLNWASQIYPGIKVKQLCKLLRGAKALTEVIPLTEEAE LELAENREILREPVHGVYYDPSKELVAEIQKQGKGQWTYQIYQEPFKNLKTGKYARMRGT HTNDVKQLVEAVQKISTESIVIWGKTPRFRLPIQKETWE |
References
| Author | Title | Citation |
| Baxter, JD | Genotypic changes in human immunodeficiency virus type 1 protease associated with reduced susceptibility and virologic response to the protease inhibitor tipranavir. | J Virol, 2006 |