<!--#if expr="$title" --> <!--#echo var="title" --> <!--#else --> HIV Drug Resistance Database <!--#endif -->
Stanford University HIV Drug Resistance Database - A curated public database designed to represent, store, and analyze the divergent forms of data underlying HIV drug resistance.

Isolate Data

Patient Isolate Region Year Species Subtype Source Clone Method
48-7098 7098-30714 Spain 2003 HIV1 B Plasma None

Treatment History
Order Regimen Weeks
1 PI|NRTI|NNRTI NA

Protease Sequence
PIMajorDRMs PIMinorDRMs Polys UnusualMuts
M46I, I54LV, I84V, L90M L10FI, L33F, G73GS, T74TP I13IV, L19LI, K20R, E35D, M36I, I62V, L63P, I66V, I72V, V82VI, I93L, C95F  
>7098-30714| codons 1-99
PQITLWQRPIVTVKIGGQIREALLDTGADDTVFEDINLPGRWKPKIIGGIGGFVKVRQYD
QVPIEVCGHKAVSPVLVGPTPINVIGRNLMTQLGFTLNF

RT Sequence
NRTIMajorDRMs NRTIMinorDRMs NNRTIMajorDRMs NNRTIMinorDRMs Polys UnusualMuts
M41L, D67N, T69D, M184I, L210W, T215Y K219R Y188L V179E K20KR, T39TA, K43KE, E44EAD, V106I, V118I, K122E, I135IV, T200A, E203D, H208Y, R211K, H221Y, D237E, V245K, E248D, D250E, A272P, T286A, G333E, Q334H, E370D, T377M, T386I, K390R  
>7098-30714| codons 1-400
PISPIETVPVKLKPGMDGPRVKQWPLTEEKIKALVEICAELEEDGKISKIGPENPYNTPV
FAIKKKNSDKWRKLVDFRELNKRTQDFWEVQLGIPHPAGLKKKKSITVLDVGDAYFSIPL
DEDFRKYTAFTIPSVNNETPGIRYQYNVLPQGWKGSPAIFQSSMTKILEPFRKQNPDIEI
YQYIDDLLVGSDLEIGQHRAKIDELRQYLWKWGFYTPDRKYQKEPPFLWMGYELHPEKWT
VQPIKLPDKESWTVNDIQKLVGKLNWASQIYPGIKVKQLCKLLRGAKALTEVIPLTEEAE
LELAENREILKEPVHGVYYDPSKDLIAEIQKQEHGQWTYQIYQEPFKNLKTGKYARMRGA
HTNDVKQLTDAVQKIAMESIVIWGKIPKFRLPIQKETWEA

References
Author Title Citation
Baxter, JD Genotypic changes in human immunodeficiency virus type 1 protease associated with reduced susceptibility and virologic response to the protease inhibitor tipranavir. J Virol, 2006