Isolate Data
| Patient | Isolate | Region | Year | Species | Subtype | Source | Clone Method |
| 48-7098 | 7098-30714 | Spain | 2003 | HIV1 | B | Plasma | None |
Treatment History
| Order | Regimen | Weeks |
| 1 | PI|NRTI|NNRTI | NA |
Protease Sequence
| PIMajorDRMs | PIMinorDRMs | Polys | UnusualMuts |
| M46I, I54LV, I84V, L90M | L10FI, L33F, G73GS, T74TP | I13IV, L19LI, K20R, E35D, M36I, I62V, L63P, I66V, I72V, V82VI, I93L, C95F |
| >7098-30714| codons 1-99 PQITLWQRPIVTVKIGGQIREALLDTGADDTVFEDINLPGRWKPKIIGGIGGFVKVRQYD QVPIEVCGHKAVSPVLVGPTPINVIGRNLMTQLGFTLNF |
RT Sequence
| NRTIMajorDRMs | NRTIMinorDRMs | NNRTIMajorDRMs | NNRTIMinorDRMs | Polys | UnusualMuts |
| M41L, D67N, T69D, M184I, L210W, T215Y | K219R | Y188L | V179E | K20KR, T39TA, K43KE, E44EAD, V106I, V118I, K122E, I135IV, T200A, E203D, H208Y, R211K, H221Y, D237E, V245K, E248D, D250E, A272P, T286A, G333E, Q334H, E370D, T377M, T386I, K390R |
| >7098-30714| codons 1-400 PISPIETVPVKLKPGMDGPRVKQWPLTEEKIKALVEICAELEEDGKISKIGPENPYNTPV FAIKKKNSDKWRKLVDFRELNKRTQDFWEVQLGIPHPAGLKKKKSITVLDVGDAYFSIPL DEDFRKYTAFTIPSVNNETPGIRYQYNVLPQGWKGSPAIFQSSMTKILEPFRKQNPDIEI YQYIDDLLVGSDLEIGQHRAKIDELRQYLWKWGFYTPDRKYQKEPPFLWMGYELHPEKWT VQPIKLPDKESWTVNDIQKLVGKLNWASQIYPGIKVKQLCKLLRGAKALTEVIPLTEEAE LELAENREILKEPVHGVYYDPSKDLIAEIQKQEHGQWTYQIYQEPFKNLKTGKYARMRGA HTNDVKQLTDAVQKIAMESIVIWGKIPKFRLPIQKETWEA |
References
| Author | Title | Citation |
| Baxter, JD | Genotypic changes in human immunodeficiency virus type 1 protease associated with reduced susceptibility and virologic response to the protease inhibitor tipranavir. | J Virol, 2006 |