<!--#if expr="$title" --> <!--#echo var="title" --> <!--#else --> HIV Drug Resistance Database <!--#endif -->
Stanford University HIV Drug Resistance Database - A curated public database designed to represent, store, and analyze the divergent forms of data underlying HIV drug resistance.

Isolate Data

Patient Isolate Region Year Species Subtype Source Clone Method
48-7095 7095-30930 Spain 2003 HIV1 B Plasma None

Treatment History
Order Regimen Weeks
1 PI|NRTI|NNRTI NA

Protease Sequence
PIMajorDRMs PIMinorDRMs Polys UnusualMuts
M46I, I54V, I84V L24I, L33F, T74P L10I, T12P, K20T, E35D, M36I, N37Q, R57K, L63P, A71V, V77I, I93L  
>7095-30930| codons 1-99
PQITLWQRPIVPIKIGGQLTEALIDTGADDTVFEDIQLPGRWKPKIIGGIGGFVKVKQYD
QIPIEICGHKVIGPVLIGPTPVNVIGRNLLTQLGCTLNF

RT Sequence
NRTIMajorDRMs NRTIMinorDRMs NNRTIMajorDRMs NNRTIMinorDRMs Polys UnusualMuts
M41L, L74V, L210W, T215Y   Y181C V108I E6D, K43E, A98S, V118I, T200I, I202T, E203EAD, R211K, H221Y, L228R, E297KR, E312EG, V317G, I329V, G335C, T369A, A371V, A376AT, K390R  
>7095-30930| codons 1-399
PISPIDTVPVKLKPGMDGPKVKQWPLTEEKIKALVEICTELEEEGKISKIGPENPYNTPV
FAIKKKDSTKWRKVVDFRELNKRTQDFWEVQLGIPHPSGLKKKKSVTILDVGDAYFSIPL
DKDFRKYTAFTIPSINNETPGIRYQYNVLPQGWKGSPAIFQSSMTKILEPFRKQNPDIVI
CQYMDDLYVGSDLEIGQHRIKTDELRQHLWKWGFYTPDKKYQKEPPFRWMGYELHPDKWT
VQPIVLPEKDSWTVNDIQKLVGKLNWASQIYAGIKVKQLCKLLRGTKALTEVIPLTREAE
LELAENREILKGPVHGGYYDPSKDLIAEVQKQGQCQWTYQIYQEPFKNLKTGKYARMRGA
HTNDVKQLAEVVQKITTESIVIWGKTPKFRLPIQKETWE

References
Author Title Citation
Baxter, JD Genotypic changes in human immunodeficiency virus type 1 protease associated with reduced susceptibility and virologic response to the protease inhibitor tipranavir. J Virol, 2006