<!--#if expr="$title" --> <!--#echo var="title" --> <!--#else --> HIV Drug Resistance Database <!--#endif -->
Stanford University HIV Drug Resistance Database - A curated public database designed to represent, store, and analyze the divergent forms of data underlying HIV drug resistance.

Isolate Data

Patient Isolate Region Year Species Subtype Source Clone Method
48-7094 7094-30930 Spain 2003 HIV1 B Plasma None

Treatment History
Order Regimen Weeks
1 PI|NRTI|NNRTI NA

Protease Sequence
PIMajorDRMs PIMinorDRMs Polys UnusualMuts
M46I, I84V, L90M G73S L10I, E35D, N37S, L63P, A71V, I93L  
>7094-30930| codons 1-99
PQITLWQRPIVTIKIGGQLKEALLDTGADDTVLEDMSLPGRWKPKIIGGIGGFIKVRQYD
QIPIEICGHKVISTVLVGPTPVNVIGRNLMTQLGCTLNF

RT Sequence
NRTIMajorDRMs NRTIMinorDRMs NNRTIMajorDRMs NNRTIMinorDRMs Polys UnusualMuts
M41L, D67DN, L74LV, L210W, T215Y   K103KNRS   K20KR, T39TA, E44D, S48T, S68SG, K101KR, V118VI, K122E, K173N, Q174K, E203K, Q207E, H208Y, R211K, K223E, E248D, A272P, L283I, P294Q, G333D, Q334H, R356K, G359S, K366R, A371V, K390R  
>7094-30930| codons 1-400
PISPIETVPVKLKPGMDGPRVKQWPLTEEKIKALVEICAELEKDGKITKIGPENPYNTPV
FAIKKKNGTKWRKVVDFRELNKRTQDFWEVQLGIPHPAGLRKSKSVTVLDVGDAYFSIPL
DEDFRKYTAFTIPSINNETPGIRYQYNVLPQGWKGSPAIFQSSMTKILEPFRNKNPDIVI
YQYMDDLYVGSDLEIGQHRTKIKELREYLWKWGFYTPDKKHQEEPPFLWMGYELHPDKWT
VQPIVLPDKDSWTVNDIQKLVGKLNWASQIYPGIKVKQLCKLIRGTKALTEVIQLTEEAE
LELAENREILKEPVHGVYYDPSKDLIAEIQKQDHGQWTYQIYQEPFKNLKTGKYAKMRSA
HTNDVRQLTEVVQKIATESIVIWGKTPKFRLPIQKETWEA

References
Author Title Citation
Baxter, JD Genotypic changes in human immunodeficiency virus type 1 protease associated with reduced susceptibility and virologic response to the protease inhibitor tipranavir. J Virol, 2006