Isolate Data
| Patient | Isolate | Region | Year | Species | Subtype | Source | Clone Method |
| 48-7094 | 7094-30930 | Spain | 2003 | HIV1 | B | Plasma | None |
Treatment History
| Order | Regimen | Weeks |
| 1 | PI|NRTI|NNRTI | NA |
Protease Sequence
| PIMajorDRMs | PIMinorDRMs | Polys | UnusualMuts |
| M46I, I84V, L90M | G73S | L10I, E35D, N37S, L63P, A71V, I93L |
| >7094-30930| codons 1-99 PQITLWQRPIVTIKIGGQLKEALLDTGADDTVLEDMSLPGRWKPKIIGGIGGFIKVRQYD QIPIEICGHKVISTVLVGPTPVNVIGRNLMTQLGCTLNF |
RT Sequence
| NRTIMajorDRMs | NRTIMinorDRMs | NNRTIMajorDRMs | NNRTIMinorDRMs | Polys | UnusualMuts |
| M41L, D67DN, L74LV, L210W, T215Y | K103KNRS | K20KR, T39TA, E44D, S48T, S68SG, K101KR, V118VI, K122E, K173N, Q174K, E203K, Q207E, H208Y, R211K, K223E, E248D, A272P, L283I, P294Q, G333D, Q334H, R356K, G359S, K366R, A371V, K390R |
| >7094-30930| codons 1-400 PISPIETVPVKLKPGMDGPRVKQWPLTEEKIKALVEICAELEKDGKITKIGPENPYNTPV FAIKKKNGTKWRKVVDFRELNKRTQDFWEVQLGIPHPAGLRKSKSVTVLDVGDAYFSIPL DEDFRKYTAFTIPSINNETPGIRYQYNVLPQGWKGSPAIFQSSMTKILEPFRNKNPDIVI YQYMDDLYVGSDLEIGQHRTKIKELREYLWKWGFYTPDKKHQEEPPFLWMGYELHPDKWT VQPIVLPDKDSWTVNDIQKLVGKLNWASQIYPGIKVKQLCKLIRGTKALTEVIQLTEEAE LELAENREILKEPVHGVYYDPSKDLIAEIQKQDHGQWTYQIYQEPFKNLKTGKYAKMRSA HTNDVRQLTEVVQKIATESIVIWGKTPKFRLPIQKETWEA |
References
| Author | Title | Citation |
| Baxter, JD | Genotypic changes in human immunodeficiency virus type 1 protease associated with reduced susceptibility and virologic response to the protease inhibitor tipranavir. | J Virol, 2006 |