<!--#if expr="$title" --> <!--#echo var="title" --> <!--#else --> HIV Drug Resistance Database <!--#endif -->
Stanford University HIV Drug Resistance Database - A curated public database designed to represent, store, and analyze the divergent forms of data underlying HIV drug resistance.

Isolate Data

Patient Isolate Region Year Species Subtype Source Clone Method
48-7093 7093-30929 Spain 2003 HIV1 B Plasma None

Treatment History
Order Regimen Weeks
1 PI|NRTI|NNRTI NA

Protease Sequence
PIMajorDRMs PIMinorDRMs Polys UnusualMuts
M46I, I54V, V82A, L90M G73S L10I, I15V, K20MV, L24LF, E35DN, M36I, N37D, D60E, I62V, L63P, A71V, I72L  
>7093-30929| codons 1-99
PQITLWQRPIVTIKVGGQLVEALFDTGADDTVLENIDLPGRWKPKIIGGIGGFVKVRQYE
QVPIEICGHKVLSTVLVGPTPANIIGRNLMTQIGCTLNF

RT Sequence
NRTIMajorDRMs NRTIMinorDRMs NNRTIMajorDRMs NNRTIMinorDRMs Polys UnusualMuts
K65R, Q151M V75I, F77L, F116Y, K219Q K101E, Y181C, G190A   K20R, S68G, T69I, V118I, K122E, Q174R, T200A, E204A, F214L, L228R, T286A, E297K, D324E, I329L, G335D, M357T, G359S, T369TA, V381I, K385R  
>7093-30929| codons 1-399
PISPIETVPVKLKPGMDGPRVKQWPLTEEKIKALVEICTEMEKEGKISKIGPENPYNTPV
FAIKRKDGIKWRKLIDLRELNKRTQDFWEVQLGIPHPAGLEKKKSVTVLDVGDAYYSIPL
DEDFRKYTAFTIPSINNETPGIRYQYNVLPMGWKGSPAIFQSSMTKILEPFRKRNPDIVI
CQYMDDLYVASDLEIGQHRAKIEALRQHLLRWGLTTPDQKHQKEPPFRWMGYELHPDKWT
VQPIVLPEKDSWTVNDIQKLVGKLNWASQIYAGIKVKQLCKLLRGAKALTEVIPLTKEAE
LELAENREILKEPVHGVYYDPSKELIAELQKQGQDQWTYQIYQEPFKNLKTGKYARTRSA
HTNDVKQLAEAVQKIATESIIIWGRTPKFKLPIQKETWE

References
Author Title Citation
Baxter, JD Genotypic changes in human immunodeficiency virus type 1 protease associated with reduced susceptibility and virologic response to the protease inhibitor tipranavir. J Virol, 2006