Isolate Data
| Patient | Isolate | Region | Year | Species | Subtype | Source | Clone Method |
| 48-7090 | 7090-30731 | Spain | 2003 | HIV1 | B | Plasma | None |
Treatment History
| Order | Regimen | Weeks |
| 1 | PI|NRTI|NNRTI | NA |
Protease Sequence
| PIMajorDRMs | PIMinorDRMs | Polys | UnusualMuts |
| M46L, L76LV, I84V | V11VI, L33F, L89V | L10I, I13V, K14R, E34EQ, N37ND, I62IV, L63P, K70KQ, A71T, I72T, P79A, Q92R |
| >7090-30731| codons 1-99 PQITLWQRPIITVRIGGQLKEALLDTGADDTVFQEMDLPGRWKPKLIGGIGGFIKVRQYD QVPIEICGHQTTGTVVVGATPVNVIGRNVLTRIGCTLNF |
RT Sequence
| NRTIMajorDRMs | NRTIMinorDRMs | NNRTIMajorDRMs | NNRTIMinorDRMs | Polys | UnusualMuts |
| M41L, D67N, K70R, M184V, L210LW, T215Y | K219Q, N348I | G190S | K32E, V35K, V60I, I135T, V245M, A272P, I293V, E297EKQ, R358K, K390R |
| >7090-30731| codons 1-399 PISPIETVPVKLKPGMDGPKVKQWPLTEEKIEALKEICTELEKEGKISKIGPENPYNTPI FAIKKKNSTRWRKLVDFRELNKRTQDFWEVQLGIPHPAGLKKKKSVTVLDVGDAYFSVPL DKDFRKYTAFTIPSTNNETPGIRYQYNVLPQGWKGSPAIFQSSMTKILEPFRKQNPDIVI YQYVDDLYVSSDLEIGQHRTKIEELRQHLWRWGFYTPDQKHQKEPPFLWMGYELHPDKWT VQPIMLPEKDSWTVNDIQKLVGKLNWASQIYPGIKVKQLCKLLRGTKALTEVVPLTQEAE LELAENREILKEPVHGVYYDPSKDLIAEIQKQGQGQWTYQIYQEPFKILKTGKYARMKGA HTNDVKQLTEAVQKIATESIVIWGKTPKFRLPIQKETWE |
References
| Author | Title | Citation |
| Baxter, JD | Genotypic changes in human immunodeficiency virus type 1 protease associated with reduced susceptibility and virologic response to the protease inhibitor tipranavir. | J Virol, 2006 |