Isolate Data
| Patient | Isolate | Region | Year | Species | Subtype | Source | Clone Method |
| 48-7086 | 7086-30612 | Spain | 2003 | HIV1 | B | Plasma | None |
Treatment History
| Order | Regimen | Weeks |
| 1 | PI|NRTI|NNRTI | NA |
Protease Sequence
| PIMajorDRMs | PIMinorDRMs | Polys | UnusualMuts |
| I54V, V82A, L90M | L33F, K43T, F53L, T74P | L10V, I13V, K20R, E35D, M36I, N37E, K55R, R57K, I62V, L63A, A71V, I72V, V77I, T91S |
| >7086-30612| codons 1-99 PQITLWQRPVVTVKIGGQLREALLDTGADDTVFEDIELPGRWTPKMIGGIGGLVRVKQYD QVAIEICGHKVVGPVLIGPTPANIIGRNLMSQIGCTLNF |
RT Sequence
| NRTIMajorDRMs | NRTIMinorDRMs | NNRTIMajorDRMs | NNRTIMinorDRMs | Polys | UnusualMuts |
| M41L, D67N, M184V, L210W, T215FY | A62V | K101KE, Y181YC, G190GA | K43N, E44D, W88CF, V118I, K122E, R211K, T286TA, A288AS, I293V, V317A, S322T, G359S | E138AT |
| >7086-30612| codons 1-400 PISPIETVPVKLKPGMDGPKVKQWPLTEEKIKALVEICTELENDGKISKIGPENPYNTPV FVIKKKNSTKWRKLVDFRELNKRTQDFFEVQLGIPHPAGLEKKKSVTVLDVGDAYFSIPL DEDFRKYTAFTIPSINNTTPGIRYQYNVLPQGWKGSPAIFQSSMTKILEPFRKQNPDIVI CQYVDDLYVASDLEIGQHRTKIEELRQHLWKWGFYTPDKKHQKEPPFLWMGYELHPDKWT VQPIVLPEKDSWTVNDIQKLVGKLNWASQIYAGIKVKQLCKLLRGAKSLTEVVPLTEEAE LELAENREILKEPVHGAYYDPTKDLIAEIQKQGQGQWTYQIYQEPFKNLKTGKYARMRSA HTNDVKQLTEAVQKIATESIVIWGKTPKFKLPIQKETWEA |
References
| Author | Title | Citation |
| Baxter, JD | Genotypic changes in human immunodeficiency virus type 1 protease associated with reduced susceptibility and virologic response to the protease inhibitor tipranavir. | J Virol, 2006 |