Isolate Data
| Patient | Isolate | Region | Year | Species | Subtype | Source | Clone Method |
| 48-7070 | 7070-30702 | Spain | 2003 | HIV1 | B | Plasma | None |
Treatment History
| Order | Regimen | Weeks |
| 1 | PI|NRTI|NNRTI | NA |
RT Sequence
| NRTIMajorDRMs | NRTIMinorDRMs | NNRTIMajorDRMs | NNRTIMinorDRMs | Polys | UnusualMuts |
| M41L, L210W | T215C, N348I | V35M, T39A, E44D, K102R, I142IV, S162A, I178M, G196GR, R211K, A272P, K277R, T286A, V292I, I293V, G333E, Q334Y, R356K, M357T, K390R |
| >7070-30702| codons 1-399 PISPIETVPVKLKPGMDGPKVKQWPLTEEKIKALMEICAELEKDGKISKIGPENPYNTPV FAIKKKDSTKWRKLVDFRELNKRTQDFWEVQLGIPHPAGLKRKKSVTVLDVGDAYFSVPL DKDFRKYTAFTIPSINNETPGVRYQYNVLPQGWKGSPAIFQASMTKILEPFRKQNPDMVI YQYMDDLYVGSDLEIRQHRTKIEELRQHLWKWGFCTPDKKHQKEPPFLWMGYELHPDKWT VQPIVLPEKDSWTVNDIQKLVGKLNWASQIYPGIKVRQLCKLLRGAKALTEIVPLTEEAE LELAENREILKEPVHGVYYDPSKDLIAEIQKQEYGQWTYQIYQEPFKILKTGKYAKTRGA HTNDVKQLTEAVQKIATESIVIWGKTPKFRLPIQKETWE |
Protease Sequence
| PIMajorDRMs | PIMinorDRMs | Polys | UnusualMuts |
| M46L, I54V, I84V | Q58E | T4TP, L10LI, I13IV, K14R, E35D, M36MI, N37S, L63P, I64V, I93L |
| >7070-30702| codons 1-99 PQIPLWQRPIVTVRIGGQLKEALLDTGADDTVLEDISLPGRWKPKLIGGIGGFVKVREYD QIPVEICGHKAIGTVLVGPTPVNVIGRNLLTQLGCTLNF |
References
| Author | Title | Citation |
| Baxter, JD | Genotypic changes in human immunodeficiency virus type 1 protease associated with reduced susceptibility and virologic response to the protease inhibitor tipranavir. | J Virol, 2006 |