<!--#if expr="$title" --> <!--#echo var="title" --> <!--#else --> HIV Drug Resistance Database <!--#endif -->
Stanford University HIV Drug Resistance Database - A curated public database designed to represent, store, and analyze the divergent forms of data underlying HIV drug resistance.

Isolate Data

Patient Isolate Region Year Species Subtype Source Clone Method
48-7064 7064-30729 Spain 2003 HIV1 B Plasma None

Treatment History
Order Regimen Weeks
1 PI|NRTI|NNRTI NA

RT Sequence
NRTIMajorDRMs NRTIMinorDRMs NNRTIMajorDRMs NNRTIMinorDRMs Polys UnusualMuts
M41L, D67N, L210W, T215Y V75M K101E, Y181C, G190S   K43N, E44D, R83K, V90I, K104R, V118VI, D123E, I178L, V179I, E203D, Q207E, H208Y, R211K, H221Y, A272P, K277R, I293V, I329V, G333E, G335C, M357K, A371V, T386I, K390R  
>7064-30729| codons 1-399
PISPIETVPVKLKPGMDGPKVKQWPLTEEKIKALVEICTELENDGKISKIGPENPYNTPV
FAIKKKNSTKWRKLMDFRELNKKTQDFWEIQLGIPHPAGLEKKRSVTVLDVGDAYFSIPL
DKEFRKYTAFTIPSINNETPGIRYQYNVLPQGWKGSPAIFQSSMTKILEPFRKQNPDLII
CQYMDDLYVSSDLEIGQHRTKIDELREYLWKWGFYTPDKKYQKEPPFLWMGYELHPDKWT
VQPIVLPEKDSWTVNDIQKLVGKLNWASQIYPGIKVRQLCKLLRGTKALTEVVPLTEEAE
LELAENREILKEPVHGVYYDPSKDLIAEVQKQEQCQWTYQIYQEPFKNLKTGKYARKRGA
HTNDVKQLTEVVQKIATESIVIWGKIPKFRLPIQKETWE

Protease Sequence
PIMajorDRMs PIMinorDRMs Polys UnusualMuts
M46I, I50V, I54V, L90M L10F, L23I, G73S, L89V I15V, K20V, E35D, M36I, N37D, D60E, Q61H, L63P, A71V, I72M, I85V, Q92K, I93L  
>7064-30729| codons 1-99
PQITLWQRPFVTIKVGGQLVEAILDTGADDTVLEDIDLPGRWKPKIIGGVGGFVKVRQYE
HIPIEICGHKVMSTVLVGPTPVNIVGRNVMTKLGCTLNF

References
Author Title Citation
Baxter, JD Genotypic changes in human immunodeficiency virus type 1 protease associated with reduced susceptibility and virologic response to the protease inhibitor tipranavir. J Virol, 2006