Isolate Data
| Patient | Isolate | Region | Year | Species | Subtype | Source | Clone Method |
| 48-7064 | 7064-30729 | Spain | 2003 | HIV1 | B | Plasma | None |
Treatment History
| Order | Regimen | Weeks |
| 1 | PI|NRTI|NNRTI | NA |
Protease Sequence
| PIMajorDRMs | PIMinorDRMs | Polys | UnusualMuts |
| M46I, I50V, I54V, L90M | L10F, L23I, G73S, L89V | I15V, K20V, E35D, M36I, N37D, D60E, Q61H, L63P, A71V, I72M, I85V, Q92K, I93L |
| >7064-30729| codons 1-99 PQITLWQRPFVTIKVGGQLVEAILDTGADDTVLEDIDLPGRWKPKIIGGVGGFVKVRQYE HIPIEICGHKVMSTVLVGPTPVNIVGRNVMTKLGCTLNF |
RT Sequence
| NRTIMajorDRMs | NRTIMinorDRMs | NNRTIMajorDRMs | NNRTIMinorDRMs | Polys | UnusualMuts |
| M41L, D67N, V75M, L210W, T215Y | K101E, Y181C, G190S | K43N, E44D, R83K, V90I, K104R, V118VI, D123E, I178L, V179I, E203D, Q207E, H208Y, R211K, H221Y, A272P, K277R, I293V, I329V, G333E, G335C, M357K, A371V, T386I, K390R |
| >7064-30729| codons 1-399 PISPIETVPVKLKPGMDGPKVKQWPLTEEKIKALVEICTELENDGKISKIGPENPYNTPV FAIKKKNSTKWRKLMDFRELNKKTQDFWEIQLGIPHPAGLEKKRSVTVLDVGDAYFSIPL DKEFRKYTAFTIPSINNETPGIRYQYNVLPQGWKGSPAIFQSSMTKILEPFRKQNPDLII CQYMDDLYVSSDLEIGQHRTKIDELREYLWKWGFYTPDKKYQKEPPFLWMGYELHPDKWT VQPIVLPEKDSWTVNDIQKLVGKLNWASQIYPGIKVRQLCKLLRGTKALTEVVPLTEEAE LELAENREILKEPVHGVYYDPSKDLIAEVQKQEQCQWTYQIYQEPFKNLKTGKYARKRGA HTNDVKQLTEVVQKIATESIVIWGKIPKFRLPIQKETWE |
References
| Author | Title | Citation |
| Baxter, JD | Genotypic changes in human immunodeficiency virus type 1 protease associated with reduced susceptibility and virologic response to the protease inhibitor tipranavir. | J Virol, 2006 |